Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
The Journal of Nutritional Biochemistry (Impact Factor: 3.79). 01/2008; 19(1):61-8. DOI: 10.1016/j.jnutbio.2007.01.006
Source: PubMed


This study assessed the effects of combined chromium picolinate (CP) and conjugated linoleic acid (CLA) supplementation on energy restriction and exercise-induced changes in body composition, glucose metabolism, lipid lipoprotein profile and blood pressure in overweight, premenopausal women. For 12 weeks, 35 women [age 36+/-1 years (mean+/-S.E.M.); BMI 28.0+/-0.5 kg/m2] were counseled to consume a 2092 kJ/day (500 kcal/day) energy deficit diet and performed 30 min of moderate-intensity walking or jogging 5 days/week. The women were randomly assigned to ingest either CP-CLA [400 mug chromium (Cr), 1.8 g CLA in 2.4 g tonalin oil, n=19] or placebo (<0.1 microg Cr, 2.4 g canola oil, n=16). Compared to baseline, urinary Cr excretion increased 22-fold, plasma CLA isomer 18:2 (c9,t11) content increased 79% and plasma CLA isomer 18:2 (t10,c12) became detectable in CP-CLA and were unchanged in Placebo. Over time, body weight decreased 3.5+/-0.5% (CP-CLA -2.6+/-0.5; placebo -2.5+/-0.5 kg) and fat mass decreased 8.9+/-1.3% (CP-CLA -2.7+/-0.5, placebo -2.4+/-0.5 kg), with no differences in responses between groups. Fasting blood hemoglobin A1c, plasma glucose and insulin, a homeostatic assessment of insulin resistance, serum total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triacylglycerol (TG), CHOL/HDL ratio, TG/HDL ratio and sitting systolic and diastolic blood pressures were not changed over time or influenced by CP-CLA. The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women.

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Available from: Bruce A Watkins, Mar 15, 2014
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    • "This study concluded that canola oil can increase cholecystokinin levels, which may, in turn, mediate the satiating effects in ileum, but not in peptide YY. Diaz et al.77 assessed the effects of the dietary supplements chromium picolinate and conjugated linoleic acid, with canola oil provided as the placebo, on energy restriction and exercise-induced changes in body weight, body composition, and body mass index in overweight premenopausal women over a period of 12 weeks. Despite the initial hypothesis that women who consumed the dietary supplements would attain lower fat deposition, higher lean mass, and greater positive changes in indexes of metabolism compared to women who consumed a placebo (canola oil), the results of this study supported the assertion that the combination of conjugated linoleic acid failed to influence losses of body weight and fat deposition compared to the placebo canola oil treatment. "
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