Cerebrovascular Function in Pregnancy and Eclampsia

Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Hypertension (Impact Factor: 6.48). 08/2007; 50(1):14-24. DOI: 10.1161/HYPERTENSIONAHA.106.079442
Source: PubMed

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    • "" It is thought that patients with chronic hypertension have hypertrophic artery walls, including in the CNS, causing reduced permeability of the blood–brain barrier. Patients with preeclampsia do not have this compensatory effect and even small increases in blood pressure, can cause them to respond with increased permeability of the blood–brain barrier [2, 3]. The above theory can be relevant in our patient's case since blood pressure had been normal throughout the pregnancy. "
    [Show abstract] [Hide abstract] ABSTRACT: Key Clinical Message Preeclampsia (PE) should be considered in women with headache who are in gestational week 20 or more, are in labor, or have recently given birth. Early diagnosis is essential to arrest disease progression and further prognosis in PE.
    Full-text · Article · Feb 2015
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    • "The most important predictor of cerebral injury is systolic tension [3, 5, 25]. What is encouraging about PRES is that this state is usually completely reversible within 7 days, presuming that prompt control of seizures and BP and expeditious delivery (in cases of prepartal eclampsia) were undertaken [3, 13, 14, 18, 21, 25]. Our therapy regimen included antiedematous therapy (sol. "
    Full-text · Article · Dec 2014
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    • "One study shows that 16% of cases of eclampsia occur in normotensive patients, and only 13% of cases were associated with severe hypertension [68, 69]. Therefore, the loss of autoregulation of cerebral perfusion secondary to hypertension does not explain all cases of PRES, so that alteration of endothelial permeability by disruption of the BBB ought to play an important role [67]. A recent study shows that preeclampsia altered BBB permeability independently of blood pressure. "
    [Show abstract] [Hide abstract] ABSTRACT: Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS), which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.
    Full-text · Article · Dec 2012 · International Journal of Hypertension
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