Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

Department of Psychology, Psychology Building, Ohio State University, Columbus, OH 43210, USA.
Neurobiology of aging (Impact Factor: 5.01). 07/2007; 29(12):1894-901. DOI: 10.1016/j.neurobiolaging.2007.04.028
Source: PubMed


The number of activated microglia increase during normal aging. Stimulation of endocannabinoid receptors can reduce the number of activated microglia, particularly in the hippocampus, of young rats infused chronically with lipopolysaccharide (LPS). In the current study we demonstrate that endocannabinoid receptor stimulation by administration of WIN-55212-2 (2mg/kg day) can reduce the number of activated microglia in hippocampus of aged rats and attenuate the spatial memory impairment in the water pool task. Our results suggest that the action of WIN-55212-2 does not depend upon a direct effect upon microglia or astrocytes but is dependent upon stimulation of neuronal cannabinoid receptors. Aging significantly reduced cannabinoid type 1 receptor binding but had no effect on cannabinoid receptor protein levels. Stimulation of cannabinoid receptors may provide clinical benefits in age-related diseases that are associated with brain inflammation, such as Alzheimer's disease.

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Available from: Yannick Marchalant
    • "ggest a dual role for cannabinoid CB 1 receptors in the context of amyloid - induced neuroinflammation . The blockade of CB 1 receptors dramatically increased the expression levels of cytokines ( IL1b , IL6 , and TNFa ) and enzyme ( iNOS ) that is coinci - dent with the previous literature showing an anti - inflammatory effect of CB 1 activation ( Marchalant et al . , 2007 , 2008 ; Molina - Holgado et al . , 2003 ; Ortega - Gutiérrez et al . , 2005 ) . However , FAAH - null mice showed exacerbated inflammation that was reversed by SR1 , which is in concordance with the previous studies using different experimental paradigms ( Mukhopadhyay et al . , 2011 ; Rajesh et al . , 2012 ) . Further studies are needed to cl"
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