National Institute on Aging Interventions Testing Program – first report, R. A. Miller et al.
© 2007 The Authors
Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2007
of hormonal, oxidative, and metabolic indices, as well as studies
of patterns of gene expression and protein profiles, and the
function of key tissues and organ systems, could help to test
specific hypotheses about NDGA-sensitive pathways relevant to
the aging process and pathogenesis of late life illnesses. Studies
of other compounds with structures or pharmacologic profiles
similar to NDGA could also be informative. Our data also provide
a rationale for evaluation of NDGA effects on mortality risks in
other varieties of mice, including other genetically heterogeneous
stocks, and potentially for parallel studies using short-lived
primates. Lastly, administration of NDGA to mice whose aging
rate is unusually slow, for example mice on calorically restricted
or methionine-restricted diets, or pituitary dwarf mutants, could
help to determine whether the pathways by which NDGA
affects survival overlap those involved in other genetic or non-
genetic models of lifespan extension in mice.
This work was supported by NIA grants AG022303 (RAM),
AG025707 and AG022308 (DEH), and AG022307 and AG13319
(RS). We wish to thank Vivian Diaz, Elizabeth Fernandez, Melissa
Han, Patricia Harrison, Bill Kohler, Pam Krason, Jessica Sewald,
and Maggie Vergara for technical support. We thank Scott
Pletcher and Andrzej Galecki for assistance in power analysis
and study design.
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