Article

The metabolic syndrome in children and adolescents: The IDF consensus

Yale University, New Haven, Connecticut, United States
The Lancet (Impact Factor: 45.22). 07/2007; 369(9579):2059-61. DOI: 10.1016/S0140-6736(07)60958-1
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    • "A quarter of the world's adults have metabolic syndrome. There is evidence that people with metabolic syndrome have twice the risk of CVD and five times risk of T2D[12]. Metabolic syndrome, syndrome X or insulin resistance syndrome is defined by the combination of 3 or more of those factors (Abdominal obesity, triglycerides TG ≥ 150mg/dL, HDL (high density lipoprotein) cholesterol < 40 mg/dL in men or < 50 mg/dL in women, systolic blood pressure (SB) ≥ 130 mmHg, diastolic blood pressure (DB) ≥ 85 mm Hg, fasting plasma glucose ≥ 100 mg/dL, glucose intolerance and insulin resistance[13]. "

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    • "Although childhood obesity is associated with comorbidities such as T2D and hypertension (HT) [2], evidence in adults indicates that abdominal adiposity is the strongest determinant of the metabolic syndrome (MetS) [16]. Therefore, WC is now included in the International Diabetes Federation's criteria for MetS in children and adolescents [17]. The main results and methodologies used in the 38 observational studies investigating the associations between sleep and abdominal adiposity in children and adolescents are presented in Table 1. "
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    ABSTRACT: The evidence for a link between sleep and cardiometabolic risk factors in children and adolescents is accumulating; however, the literature has not yet been reviewed. Seventy-five studies investigating associations between sleep variables and measures of abdominal adiposity, glucose homeostasis, blood lipids, blood pressure (BP), and inflammatory markers were included in the present review. The current evidence indicates that inadequate sleep may play a role in cardiometabolic risk at a later age for children and adolescents. Most compelling is the evidence for an association between inadequate sleep and abdominal adiposity, decreased insulin sensitivity as well as high BP, whereas the evidence for potential links between sleep and blood lipids as well as inflammatory markers is less convincing. It should, however, be noted that the majority of studies linking sleep with cardiometabolic outcomes are cross-sectional in nature, and sleep is often assessed using parent or self-report. We suggest that future studies should investigate longitudinal associations between sleep and cardiometabolic risk factors with the use of objective sleep measurements conducted for several days, including weekdays and weekend days, at multiple time points over time. Meanwhile, based on the available evidence, we recommend that children and adolescents get adequate amounts of good sleep in a regular pattern.
    No preview · Article · Sep 2015 · Sleep Medicine Reviews
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    • "years in Sfax City according to the International Diabetes Federation (IDF) guidelines definition [13] "
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    ABSTRACT: Objective: The metabolic syndrome (MetS) has become one of the major public-health challenges worldwide. Early identification of metabolic complications consist an essential target for youth public health. We aimed to evaluate the prevalence of MetS and its components among overweight and obese adolescents. Methods: This cross-sectional study concerned 51 overweight and obese adolescents. Anthropometric assessments, blood pressure measurement and biochemical assessment were done. MetS was defined according to the International Diabetes Federation (IDF) criteria. All data were collected during one academic school year in 2012 and 2013. Results: The prevalence of the MetS was 21.6%. There was no gender difference in prevalence of MetS (P=0.09). Obese subjects had the highest proportion of MetS than overweight (25% vs. 15.8%; p=0.04). 35.3% of subjects had at least two abnormalities of MetS. Abdominal obesity was the most common individual component of the MetS (91.3 %) followed by low HDL cholesterol (58.8%). Body mass index (BMI), Waist circumference (WC), Waist to hip ratio (WRH) and Neck circumference (NC) had partial positive correlation with Blood pressure (BP), and Triglyceride. Similarly, (BP), Triglyceride and HDL cholesterol were significantly higher in subjects with metabolic syndrome than that of subjects without metabolic syndrome (p < 0.05). Conclusion: MetS is prevalent in our young population in Sfax City. The results of this study will help in planning to control these problems in the future. So we suggest screening programs for secondary school adolescent to control obesity and MetS in Tunisia.
    Full-text · Article · Mar 2015
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