Article

Anaplastic Large Cell Lymphoma Arising in a Saline Breast Implant Capsule After Tissue Expander Breast Reconstruction

Department of Surgery, Tufts University, Бостон, Georgia, United States
Annals of Plastic Surgery (Impact Factor: 1.49). 08/2007; 59(1):56-7. DOI: 10.1097/SAP.0b013e31804d442e
Source: PubMed
0 Followers
 · 
7 Reads
  • Source
    • "For example, there are no published data regarding the incidence of breast primary ALCL. Overall, there is no conclusive prospective epidemiologic evidence regarding an association between ALCL and breast implants (Mellemkjaer et al., 2000; Brinton et al., 2001; Brisson et al., 2006; Friis et al., 2006; McLaughlin et al., 2006; Deapen et al., 2007; Lipworth et al., 2009a), with the current evidence being based on several case reports and a single case–control study (Sahoo et al., 2003; Fritzsche et al., 2006; Olack et al., 2007; De Jong et al., 2008; Newman et al., 2008; Roden et al., 2008; Wong et al., 2008; Bishara et al., 2009; Miranda et al., 2009). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Large studies suggest that the overall rate of lymphoma in women with breast implants is no greater than in the general population; clinical reports suggest an association between breast implants and the rare non-Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL). Observed cases of lymphoma reported in Allergan-sponsored breast implant clinical studies were compared with expected cases on the basis of the incidence of lymphoma among women in the National Cancer Institute's Surveillance Epidemiology and End Results program, using standardized incidence ratios (SIRs) and 95% confidence intervals (CIs). In clinical studies, there were 28 observed cases of lymphoma among 89 382 patients and 204 682 person-years of follow-up compared with 43 expected cases [SIR: 28/43=0.65 (95% CI: 0.43-0.94), P=0.02]. SIRs were calculated stratifying by baseline cancer history: women without prior cancer [SIR: 17/24=0.70 (95% CI: 0.41-1.13), P=0.17] and women with prior cancer [SIR: 11/14=0.79 (95% CI: 0.39-1.41), P=0.52]. SIRs were calculated by implant shell type: textured shell implants [SIR: 16/23=0.70 (95% CI: 0.40-1.13), P=0.16] and smooth shell implants [SIR: 12/19=0.63 (95% CI: 0.33-1.10), P=0.12]. Surveillance Epidemiology and End Results reported 12 cases of primary breast ALCL in women between 1996 and 2007 without a history of cancer, for an average annual incidence of 4.28 (95% CI: 3.51-5.05)/100 million women in the US - these women may or may not have breast implants. In clinical studies, three ALCL cases were reported in women with breast implants and a history of breast cancer, yielding a crude incidence rate of 1.46 (95% CI: 0.30-4.3)/100 000 person-years. Large clinical studies, based on over 200 000 person-years of follow-up, suggest no evidence of an increased risk of lymphoma among women who have received breast implants.
    Full-text · Article · May 2012 · European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP)
  • Source
    • "52 Esthétique Non 168 Oui Oui Silicone Mc Ghan Capsulectomie ablation prothèse Chirurgie Chimiothérapie Olack et al. [21] "
    [Show abstract] [Hide abstract]
    ABSTRACT: There is a new concern about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The purpose of this review was to identify and analyze all reported cases of ALCL occurring in patients with breast implants. Therefore, we reviewed all articles published concerning this subject between 1991 and 2011. We found 41 cases of ALCL. The mean age of the patients was 51 years old with an average of 108 months between the implantation and the diagnosis. Over 60 % of the reported cases were aesthetic augmentations. However, none of the published study managed to highlight a correlation between the prosthesis and this lymphoma. Therefore, we believe that for the moment, we can reassure our patients, but we must be aware of this association if a late seroma or a tumefaction occur on prosthesis. The surgical management seems to be essential for the diagnosis and the treatment, especially by the negative ALK and CD 30 expression of this lymphoma.
    Full-text · Article · Feb 2012 · Annales de chirurgie plastique et esthetique
  • Source
    • "52 Esthétique Non 168 Oui Oui Silicone Mc Ghan Capsulectomie ablation prothèse Chirurgie Chimiothérapie Olack et al. [21] "
    [Show abstract] [Hide abstract]
    ABSTRACT: There is a new concern about a possible association between anaplastic large cell lymphoma (ALCL) and breast implants. The purpose of this review was to identify and analyze all reported cases of ALCL occurring in patients with breast implants. Therefore, we reviewed all articles published concerning this subject between 1991 and 2011. We found 41 cases of ALCL. The mean age of the patients was 51 years old with an average of 108 months between the implantation and the diagnosis. Over 60 % of the reported cases were aesthetic augmentations. However, none of the published study managed to highlight a correlation between the prosthesis and this lymphoma. Therefore, we believe that for the moment, we can reassure our patients, but we must be aware of this association if a late seroma or a tumefaction occur on prosthesis. The surgical management seems to be essential for the diagnosis and the treatment, especially by the negative ALK and CD 30 expression of this lymphoma.
    Full-text · Article · Feb 2012 · Annales de Chirurgie Plastique Esthétique
Show more