Frovatriptan for The Prevention of Postdural Puncture Headache

Ospedale San Pietro Fatebenefratelli, Roma, Latium, Italy
Cephalalgia (Impact Factor: 4.89). 08/2007; 27(7):809-13. DOI: 10.1111/j.1468-2982.2007.01327.x
Source: PubMed


Bussone G, Tullo V, d'Onofrio F, Petretta V, Curone M, Frediani F, Tonini C & Omboni S. Frovatriptan for the prevention of postdural puncture headache. Cephalalgia 2007; 27:809–813. London. ISSN 0333-1024
Efficacy of 5-day treatment with oral frovatriptan 2.5 mg/die for the prophylaxis of post-dural puncture headache (PDPH) was tested in 50 in-patients. A mild headache occurred in 7 (14%) patients for a total of 9 days (p < 0.01 vs. no-PDPH). Most episodes of PDPH occurred in the first days of treatment (only 1 patient had headache at dismissal): 5 patients had only 1 episode, while 2 had headache for 2 consecutive days. No other symptoms were recorded. Occurrence of PDPH in a subgroup of 6 (12%) patients previously submitted to a diagnostic lumbar puncture was also examined: 4 of them reported a PDPH on the previous lumbar puncture in absence of triptans. In only 1 of these 4 patients PDPH recurred under treatment with frovatriptan. In conclusion, our non-randomized open-label study suggests efficacy of oral frovatriptan for PDPH prevention. These results need to be confirmed in a randomized, controlled, double-blind study.

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Available from: Stefano Omboni, Sep 13, 2014
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