FNA diagnosis of retroperitoneal leiomyosarcoma metastasizing to the breast
Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA.Diagnostic Cytopathology (Impact Factor: 1.12). 08/2007; 35(8):508-11. DOI: 10.1002/dc.20664
Fine-needle aspiration (FNA) biopsy is one of the first-line investigations in any breast lump, and hence cytomorphological recognition of nonmammary metastatic tumors to the breast and their distinction from primary tumors is important. Breast metastasis from extra-mammary malignancy is rare, constituting 2% of breast tumors; even rarer are metastatic leiomyosarcomas. Our patient presented with a breast lump 2 years after operative removal of a retroperitoneal leiomyosarcoma. The breast lump was confirmed to be a metastasis from the earlier primary. Herein, we report the first case of a retroperitoneal leiomyosarcoma metastatic to the breast diagnosed by Fine Needle Aspiration.
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ABSTRACT: Spindle cell lesions of soft tissue and bone encompass a wide spectrum of benign and malignant conditions. They include reactive lesions such as granulomatous inflammation, pseudosarcomas such as nodular fasciitis, benign mesenchymal tumors such as neurofibroma and schwannoma, low and high-grade sarcomas, spindle cell carcinoma, and spindle cell melanoma. The sarcomas that can be presented as spindle cells include fibrosarcoma (FS), leiomyosarcoma (LMS), synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), Kaposi sarcoma, low-grade fibromyxoid sarcoma, gastrointestinal stromal tumor (GIST), and some angiosarcomas1,2 (Table 3.1).
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