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Van Lint, P. & Libert, C. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J. Leukocyte Biol. 82, 1375-1381

Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.
Journal of Leukocyte Biology (Impact Factor: 4.29). 01/2008; 82(6):1375-81. DOI: 10.1189/jlb.0607338
Source: PubMed

ABSTRACT

The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

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Available from: Philippe Van Lint, May 04, 2015
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    • "They are also associated with cleavage of cell surface receptors , the release of apoptotic ligands (like the FAS ligand ), and chemokine/cytokine in/activation. MMPs also play a major role cell proliferation, migration (adhesion/ dispersion), differentiation, apoptosis, and host defense[106]. MMP-9, also known as 92 kDa type IV collagenase or gelatinase B, can be involved in the degradation of collagen IV present in the basement membrane and extracellular matrix. In rosacea-associated meibomian gland disease or Sjogren's syndrome, the tear activity of MMP9 was raised compared to controls[30]. "
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    • "MMPs aid in establishing a chemotactic signal for recruitment of leukocytes and at the same time degrade ECM and junctional proteins, promoting leukocyte infiltration. Chemokines are immobilized mostly on the ECM or cell surface by binding to glycosaminoglycans and MMPs might contribute to the liberation of these molecules, delivering soluble effectors in the extracellular environment [8]. Paracellular movement of leukocytes is impeded by tight junctions and adherens junctions that occlude the intercellular cleft. "
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    • "UV irradiation induces the expression of MMPs and triggers cleavage of cell-surface receptors and protein kinase signal transduction pathways and activation of transcription factors (Fisher et al., 2002). MMPs degrade all kinds of extracellular matrix proteins and damage connective tissues (Kahari and Saarialho- Kere, 1997) and induce the release of cytokines and chemokines and cleave cell surface receptors (Van and Libert, 2007). They also play a role in tissue remodeling and disease processes such as arthritis (Burrage et al., 2006). "
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