A potential role for F-18 FDG PET/CT in evaluation and management of Fibrosing mediastinitis

Louisiana State University in Shreveport, Shreveport, Louisiana, United States
Clinical Nuclear Medicine (Impact Factor: 3.93). 10/2007; 32(9):703-6. DOI: 10.1097/RLU.0b013e318125035b
Source: PubMed


Fibrosing mediastinitis is an uncommon benign disorder, and its pathogenesis and management remain unclear. Conventional imaging techniques (chest radiographs, CT, MRI) may suggest its diagnosis but are frequently nonspecific, and it frequently mimics a malignant process by presenting as a mediastinal mass without calcifications, encasing, and infiltrating adjacent mediastinal structures, and showing an overall aggressive behavior. The value of FDG PET imaging in this entity remains largely unknown with only a few case reports in the literature, and often, biopsy is necessary for definitive diagnosis. We report a case of biopsy proven fibrosing mediastinitis highlighting the utility of PET in the evaluation and management of the disease.

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    • "In case of complications, surgical interventions are performed to relieve the compressed mediastinal structures[18]. Patients are usually followed up by CT scan; however, PET scanning has also been reported to be an effective tool to follow disease activity[15]. In our case, baseline PET scanning showed an intense metabolic activity that decreased after treatment, suggesting that PET scanning can be used to assess disease activity over time. "
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