Article

Diffusion Tensor Imaging of the Superior Longitudinal Fasciculus and Working Memory in Recent-Onset Schizophrenia

Department of Psychology, University of California, Los Angeles, California 90095-1563, USA.
Biological psychiatry (Impact Factor: 10.26). 04/2008; 63(5):512-8. DOI: 10.1016/j.biopsych.2007.06.017
Source: PubMed

ABSTRACT

Structural and functional abnormalities in frontal-parietal circuitry are thought to be associated with working memory (WM) deficits in patients with schizophrenia. This study examines whether recent-onset schizophrenia is associated with anatomical changes in the superior longitudinal fasciculus (SLF), the main frontal-parietal white matter connection, and whether the integrity of the SLF is related to WM performance.
We applied a novel registration approach (Tract-Based Spatial Statistics [TBSS]) to diffusion tensor imaging data to examine fractional anisotropy (FA) in the left and right SLF in 12 young adult patients with recent-onset schizophrenia and 17 matched control subjects.
Schizophrenia patients showed lower FA values than control subjects across the entire SLF, with particular deficits on the left SLF. Fractional anisotropy values were correlated with performance on a verbal WM task in both patient and control groups in the left but not right SLF.
Recent-onset schizophrenia patients show deficits in frontal-parietal connections, key components of WM circuitry. Moreover, the integrity of this physiological connection predicted performance on a verbal WM task, indicating that this structural change may have important functional implications. These findings support the view that schizophrenia is a disorder of brain connectivity and implicate white matter changes detectable in the early phases of the illness as one source of this dysfunction.

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Available from: Katherine H Karlsgodt
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    • "nia reported decreased FA in a majority of white matter tracts. Such abnormalities have been hypothesized to be related to myelin deficiency, observed in post mortem and genetic studies (see review inKubicki et al., 2007). In the case of tract-specific studies, bilateral as well as unilateral FA differences of the SLF have been previously reported.Karlsgodt et al. (2008)reported on a recent onset schizophrenic sample, where they found bilateral differences in the SLF, without separating it into the I, II, and III subdivisions proposed byMakris et al. (2005). Further, Jones et al. (2006reported differences in the left SLF in late onset schizophrenia. None of these studies, however, have separated SLF int"
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