Sevoflurane anesthesia decreases cardiac vagal activity and heart rate variability

ArticleinClinical Autonomic Research 17(6):370-4 · January 2008with8 Reads
DOI: 10.1007/s10286-007-0437-9 · Source: PubMed
We evaluated cardiac vagal activity during sevoflurane anesthesia in neurosurgical patients. Heart rate variability was determined by power spectral analysis and entropy with the patient awake and during sevoflurane anesthesia. High frequency power (0.15-0.50 Hz) and heart rate entropy decreased during sevoflurane and these effects were significantly correlated (r = 0.71 +/- 0.12, P < 0.05). The results confirm that cardiac vagal activity was the primary determinant of heart rate variability, which was attenuated by sevoflurane.
    • "[11] Paisansathan demonstrated that sevoflurane anesthesia decreased cardiac vagal activity and heart rate variability. [12] Fentanyl has an anti-tussive and an anti-nociceptive effect. [10] In large doses of 6 μg/kg it has been shown to obliterate the pressor response to tracheal intubation completely. "
    [Show abstract] [Hide abstract] ABSTRACT: Drug combinations can be used for optimum obtundation of the hemodynamic response to tracheal intubation. The objective of this trial was to compare the hemodynamic response to laryngoscopy and tracheal intubation after administration of 2 μg/kg fentanyl bolus or a placebo with 2% end tidal sevoflurane at induction of anesthesia. A total of 70 surgical patients of either gender, age 18-45 years were selected for this double blind, randomized, placebo controlled trial, with 35 in each group. All patients received a standardized induction with thiopentone, atracurium, and an end tidal concentration of 1 minimum alveolar concentration (MAC) sevoflurane. Heart rate and noninvasive blood pressure were compared to the baseline post induction and for seven minutes post intubation. Some adverse events were noted. The maximum heart rate response was significantly less in the sevoflurane fentanyl group (15% vs. 22%). Significant difference between groups was observed in the systolic blood pressure at six minutes post intubation. Hemodynamic adverse events recorded were similar. Addition of 2 μg fentanyl bolus to 1 MAC sevoflurane anesthesia at induction attenuated the hemodynamic response to a maximum of 15% above baseline values.
    Full-text · Article · Oct 2011
  • Full-text · Article · · Anesthesiology
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    Full-text · Article · Jan 2009
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