Sever, M.L. et al. Cockroach allergen reduction by cockroach control alone in low-income urban homes: a randomized control trial. J. Allergy Clin. Immunol. 120, 849-855

North Carolina State University, Raleigh, North Carolina, United States
Journal of Allergy and Clinical Immunology (Impact Factor: 11.48). 11/2007; 120(4):849-55. DOI: 10.1016/j.jaci.2007.07.003
Source: PubMed


We previously reported significant reductions in cockroach allergen concentrations in urban homes by reducing cockroach infestations.
To determine the effectiveness of pest control performed by professional entomologists, compared with commercial companies, in reducing cockroach allergen.
This 3-arm randomized controlled trial enrolled 60 cockroach-infested homes in North Carolina. Homes were randomly assigned to a control group or 1 of 2 treatment groups. Treatment 1 had insecticide baits placed by entomologists from North Carolina State University. Treatment 2 received pest control from a randomly assigned commercial company. Vacuumed dust sampling and cockroach trapping were conducted at 0, 6, and 12 months. Dust samples were analyzed by ELISA.
In treatment 1 homes, there were significant reductions in geometric mean trap counts compared with control and treatment 2 homes at 12 months. Relative to control, significant 12-month reductions in Bla g 1 were evident in treatment 1 homes at all sampled sites, except bedroom floor. From baseline to month 12, geometric mean Bla g 1 concentrations (U/g) decreased from 64.2 to 5.6 in kitchen, 10.6 to 1.1 in living room, 10.7 to 1.9 on bedroom floor, and 3.6 to 2.3 in bed. Treatment 2 homes showed no significant 12-month allergen reductions versus control.
Reductions in Bla g 1 in cockroach-infested homes can be achieved by reducing infestations; however, the magnitude of allergen reduction is dependent on the thoroughness and effectiveness of cockroach eradication efforts.
Elimination of cockroaches is an effective method for reducing exposure to cockroach allergen.

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    • "HDEs were prepared as described previously by Sever et al. (2007). Endotoxin levels were assayed by a Limulus amebocyte lysate assay (Lonza, Karlsruhe, Germany), and allergens were measured using a multi plex array for indoor allergens (MARIA; Indoor Biotechnologies, Charlottesville, VA), according to the manu‑ facturer's instructions. "
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    • "Such treatment, together with family education, will be effective in reducing cockroach populations for 2-3 months [22]. Treatment by professional entomologists was found to be more effective in reducing cockroach allergen when compared to treatment by chemical companies [23]. Reduction in cockroach allergen can be achieved through combined intervention of occupant education, insecticide application and professional cleaning [6]. "
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    • "The results of this study support the latest Þndings that cockroach allergen concentrations can be re - duced by integrating several tactics including educa - tion , cleaning , and pest control ( Arbes et al . 2003 , Peters et al . 2007 ) or by cockroach elimination alone ( Arbes et al . 2004 , Sever et al . 2007 ) . School districts that are hesitant to adopt IPM methods because of skepticism about the effectiveness of this pest control approach can be encouraged to implement IPM pro - grams because both prospective and retrospective studies show that IPM is more effective than conven - tional pest control , and it can lead to long - term re - "
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