Article

N-Glycosylthioureido Aglyco-ristocetins without Platelet Aggregation Activity

Department of Pharmaceutial Chemistry, University of Debrecen.
The Journal of Antibiotics (Impact Factor: 1.73). 09/2007; 60(8):529-33. DOI: 10.1038/ja.2007.68
Source: PubMed

ABSTRACT

The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.

Show more