Sudden Infant Death Syndrome and Maternal Depression

Health Services and Population Research Department, Institute of Psychiatry, United Kingdom.
The Journal of Clinical Psychiatry (Impact Factor: 5.5). 09/2007; 68(8):1279-83. DOI: 10.4088/JCP.v68n0816
Source: PubMed


To investigate whether there is an association between sudden infant death syndrome (SIDS) and perinatal depression.
A case-control study design was used. Cases included women registered in a British primary care database with a live birth (1987-2000) and a subsequent SIDS death. Controls were women with a live birth born in the same year as the matched SIDS death, with infant survival for the first year of life.
One hundred sixty-nine linked mother-infant cases of SIDS were matched with 662 mother-infant controls. The authors found that SIDS was independently associated with maternal depression in the year before birth (odds ratio [OR] = 4.93, 95% CI = 1.10 to 22.05), smoking (OR = 2.50, 95% CI = 1.29 to 4.88), and male sex (OR = 1.94, 95% CI = 1.04 to 3.64). There was weak evidence of an independent association of SIDS with depression in the 6 months after birth, before the index SIDS death (OR = 1.80, 95% CI = 0.71 to 4.56).
This study provides further evidence for an association between SIDS and perinatal depression, particularly antenatal depression. Health care professionals should ensure that women with perinatal depression are appropriately treated and are provided with clear advice on infant care practices that may prevent SIDS.

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    • "There was strong evidence – including from meta-analysis and two UK longitudinal studies -on links between ante-or postnatal depression and the following birth and child or adolescent outcomes until age 16: pre-term birth, infant death, teacherreported special educational needs and leaving school without qualifications, emotional problems and conduct problems (Sanderson et al., 2002; Howard et al., 2007; Halligan et al., 2007; Grote et al., 2010; Murray et al., 2010; Bauer et al., 2015). Studies controlled for a wide range of covariates such as previous maternal depression, co-existing perinatal anxiety and socio-demographic characteristics. "
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    ABSTRACT: Anxiety and depression are common among women during pregnancy and the year after birth. The consequences, both for the women themselves and for their children, can be considerable and last for many years. This study focuses on the economic consequences, aiming to estimate the total costs and health-related quality of life losses over the lifetime of mothers and their children. Method A pathway or decision modelling approach was employed, based on data from previous studies. Systematic and pragmatic literature reviews were conducted to identify evidence of impacts of perinatal anxiety and depression on mothers and their children. Results The present value of total lifetime costs of perinatal depression (anxiety) was £75,728 (£34,811) per woman with condition. If prevalence estimates were applied the respective cost of perinatal anxiety and depression combined was about £8,500 per woman giving birth; for the United Kingdom, the aggregated costs were £6.6 billion. The majority of the costs related to adverse impacts on children and almost a fifth were borne by the public sector. Limitations The method was exploratory in nature, based on a diverse range of literature and encountered important data gaps. Conclusions Findings suggest the need to allocate more resources to support women with perinatal mental illness. More research is required to understand the type of interventions that can reduce long-term negative effects for both mothers and offspring.
    No preview · Article · Dec 2015 · Journal of Affective Disorders
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    • "In addition to the negative effects for the mother, the foetus may also be affected by maternal depression . This will lead to premature delivery and lower birth weight [Bennett et al. 2004; Weinstock, 2005; Eberhard-Gran et al. 2006; Boyd et al. 2006; Howard et al. 2007], more emotional problems , hyperactivity and attention deficit hyperactivity disorder (ADHD) at a later age [Weinstock, 2005]. The latter two outcomes are associated with more morbidity and increased mortality [Bennett et al. 2004]. "
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    ABSTRACT: Data about adherence of antidepressants during pregnancy are lacking. However, it is important to gain insight into adherence in this population to reduce perinatal risks for relapse of depression. The objective of this study was to search for an inexpensive and easy method to implement daily for assessing medication adherence during pregnancy. An observational study was conducted to measure adherence by comparing pill count, Beliefs about Medicine questionnaire (BMQ) and blood level monitoring against the standard, the Medication Event Monitoring System (MEMS). We used a logistic regression model to determine potential predictors for poor adherence (age, marital class, highest level of education, monthly net income, employment, smoking, alcohol use and type of antidepressant). From January 2010 until January 2012, 41 women were included within the first trimester of pregnancy; data could be evaluated in 29 women. Using MEMS, 86% of the women took in more than 80% of all prescribed doses on time and could be classified as adherent. Pill counts showed good agreement with MEMS. We did not find predictors for poor adherence in our study population. Adherence of antidepressants during pregnancy using MEMS is 86%. There was a good agreement between MEMS and pill counts. This method may serve as a good alternative that can be easily implemented into daily practice.
    Full-text · Article · Apr 2014 · Therapeutic Advances in Psychopharmacology

  • No preview · Article · Sep 2008 · Evidence-based mental health
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