What is the Evidence for Viscosupplementation in the Treatment of Patients with Hip Osteoarthritis? Systematic Review of the Literature

Department of Orthopaedic Surgery, A.M.C, Amsterdam, The Netherlands.
Archives of Orthopaedic and Trauma Surgery (Impact Factor: 1.6). 10/2007; 128(8):815-23. DOI: 10.1007/s00402-007-0447-z
Source: PubMed


Osteoarthritis (OA) is a disease of the synovial joints and is the most common cause of chronic pain in the elderly. One of the treatment modalities for OA of the hip is viscosupplementation (VS). Today there are several different formulations of viscosupplements produced by different manufactures of different molecular weights. The objective of this review is to asses the efficacy of VS treatment of hip OA osteoarthritis in the current literature.
The following databases were searched: Medline (period 1966 to November 2006), Cochrane Database of Systematic Reviews (1988 to November 2006), Cochrane Clinical Trial Register (1988 to November 2006), Database of Abstracts on Reviews and Effectiveness, Current Controlled Trials, National Research Register and Embase (January 1988 to November 2006). The search terms [osteoarthritis, hip (joint), viscosupplementation, hyaluronic acid, hyaluronan, sodium hyaluronate and trade names] were applied to identify all studies relating to the use of VS therapy for OA of the hip joint.
Sixteen articles concerning the efficacy of a total of 509 patients undergoing VS treatment for hip OA were included. Twelve European studies, three Turkish studies and one American study with Levels of Evidence ranging from I to IV evaluated the following products: Hylan G-F 20, Hyalgan, Ostenil, Durolane, Fermatron and Orthovisc. Heterogeneity of included studies did not allow pooled analysis of data.
Despite the relatively low Level of Evidence of the included studies, VS performed under fluoroscopic or ultrasound guidance seems an effective treatment and may be an alternative treatment of hip OA. Intra-articular injection of (derivatives of) HA into the hip joint appears to be safe and well tolerated. However, VS cannot be recommended as standard therapy in hip OA for wider populations, and therefore the indications remain a highly individualised matter.

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    • "They stressed the results of the Italian cohort [35] including 1906 patients (4002 injections) strongly suggest a long-lasting beneficial effect of ultrasound-guided injections of HA in a large proportion of patients. All the experts concluded that prospective randomized controlled trials remained to be performed, particularly with cross-linked single-injection products that seem to give rather good results in non-controlled pilot trials [36] [37] [38] [39] [40] [41]. Predictive factors of response according to the OA phenotype must also be studied [42]. "
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    ABSTRACT: Viscosupplementation (VS) with hyaluronic acid is currently used by physicians to treat osteoarthritis. However, many aspects of this treatment remain questionable and subject of controversy. A group of 8 experts in this field, from European countries, met to debate on 24 statements previously listed by the group members. Based on an extensive research of the literature and expert opinion, a consensus position has been proposed for each statement. Agreement was achieved on some recommendations. In particular, the expert achieved unanimous agreement in favor of the following statements: VS is an effective treatment for mild to moderate knee OA; VS is not an alternative to surgery in advanced hip OA; VS is a well-tolerated treatment of knee and other joints OA; VS should not be used only in patients who have failed to respond adequately to analgesics and NSAIDs; VS is a "positive" indication but not a "lack of anything better" indication; the dosing regimen must be supported by evidence-based medicine; cross-linking is a proven means for prolonging IA residence time of HA; the best approach to inject accurately knee joint is the lateral mid-patellar one; when VS is performed under fluoroscopy, the amount of radiopaque contrast agent must be as low as possible to avoid viscosupplement dilution. These clear recommendations have been established to help practitioners in the use of viscosupplementation. Copyright © 2015 Elsevier Inc. All rights reserved.
    Full-text · Article · Apr 2015 · Seminars in Arthritis and Rheumatism
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    • "Viscosupplementation injections for the management of osteoarthritis of the hip have been demonstrated to be both safe and effective [1] [2] [3] [4] [5] [6] [7] [8] [9]. Acute injection related synovitis is observed in approximately 5–10% of patients undertaking this treatment, but these reactions are characteristically transient without longer-term clinical effects [10] [11] [12] [13] [14] [15]. "
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    ABSTRACT: We present the diagnosis of bilateral granulomatous inflammation of the hip joints associated with Hylan G-F 20 viscosupplementation injections. Clinicians recommending therapeutic Hylan injections for the management of hip arthritis should maintain clinical awareness regarding this potential complication.
    Full-text · Article · Aug 2014
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    • "Nevertheless published data suggest that intra-articular injections of HA in hip OA may be effective. Another literature review showed a relatively low level of evidence of the included studies, although the authors concluded that intra-articular injection of HA, performed under fluoroscopic or ultrasound guidance seems to be an effective treatment and may be an alternative treatment of hip OA [14]. Double-blind, controlled studies with a higher level of evidence are required to confirm these data. "
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    ABSTRACT: Although intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designed studies on hip osteoarthritis treatment as this subject is still very much under debate. Randomized, controlled trial with a three-armed, parallel-group design. Approximately 315 patients complying with the inclusion and exclusion criteria will be randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine.The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at six weeks, 3 and 6 months after the initial injection: Pain (100 mm VAS), Harris Hip Score and HOOS, patient assessment of their clinical status (worse, stable or better then at the time of enrollment) and intake of pain rescue medication (number per week). In addition patients will be asked if they have complications/adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered. This randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine. NCT01079455.
    Full-text · Article · Nov 2010 · BMC Musculoskeletal Disorders
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