Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment

ArticleinPharmacoepidemiology and Drug Safety 16(12):1285-9 · December 2007with1 Read
Impact Factor: 2.94 · DOI: 10.1002/pds.1476 · Source: PubMed


    An exemplary case report of a patient who developed an unpredictable sudden, late-onset clozapine-related life-threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/mu L, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature. Copyright (c) 2007 John Wiley & Sons, Ltd.