Calzavara R, Mailly P, Haber SN. Relationship between the corticostriatal terminals from areas 9 and 46, and those from area 8A, dorsal and rostral premotor cortex and area 24c: an anatomical substrate for cognition to action. Eur J Neurosci 26: 2005-2024

Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, New York 14642, USA.
European Journal of Neuroscience (Impact Factor: 3.18). 11/2007; 26(7):2005-24. DOI: 10.1111/j.1460-9568.2007.05825.x
Source: PubMed


Our previous data indicate that there are specific features of the corticostriatal pathways from the prefrontal cortex. First, corticostriatal pathways are composed of focal, circumscribed projections and of diffuse, widespread projections. Second, there is some convergence between terminal fields from different functional regions of the prefrontal cortex. Third, anterior cingulate projections from area 24b occupy a large region of the rostral striatum. The goal of this study was to determine whether these features are also common to the corticostriatal projections from area 8A (including the frontal eye field; FEF), the supplementary eye field (SEF), dorsal and rostral premotor cortex (PMdr) and area 24c. Using a new approach of three-dimensional reconstruction of the corticostriatal pathways, along with dual cortical tracer injections, we mapped the corticostriatal terminal fields from areas 9 and 46, 8A-FEF, SEF, PMdr and 24b and c. In addition, we placed injections of retrogradely transported tracers into key striatal regions. The results demonstrated that: (i) a diffuse projection system is a common feature of the corticostriatal projections from different frontal regions; (ii) key striatal regions receive convergent projections from areas 9 and 46 and from areas 8A-FEF, SEF, PMdr and 24c, suggesting a potential pivotal role of these striatal regions in integrating cortical information; (iii) projections from area 24c, like those from area 24b, terminate widely throughout the striatum, interfacing with terminals from several frontal areas. These features of the corticostriatal frontal pathways suggest a potential integrative striatal network for learning.

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    • "We focused on the dorsal caudate nucleus, given its strong associations with cognitive control and associated cortical regions (e.g., the dorsolateral prefrontal cortex; Haber et al. 2000; Draganski et al. 2008). We focused on the dorsal-anterior putamen, because it is known to be a target of dopaminergic-mediated connectivity from the dorsal caudate nucleus (Haber et al. 2000), while being strongly associated with premotor cortex (e.g., the rostral cingulate motor areas) as well as lateral prefrontal cortex (Calzavara et al. 2007; Draganski et al. 2008; Helmich et al. 2010). Note that although the rostral cingulate motor area is implicated in premotor functions [e.g., by sending direct projections to the spinal cord (He et al. 1995) and primary motor cortex (Dum and Strick 2002)], this area is also associated with negative affect, pain, and cognitive control (Shackman et al. 2011). "
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    • "However, the fact that SEF also represented the precursor signals necessary to compute reward prediction error suggests instead an alternative possibility . SEF could compute the reward prediction error signals locally without input from other structures and send them to the dopaminergic midbrain nuclei and the habenula via connections through the basal ganglia (Calzavara et al., 2007; Hong and Hikosaka, 2008). In addition, local computation of reward prediction error could occur also in other cortical areas, as suggested by recent studies in OFC (Sul et al., 2010) and ACC (Seo and Lee, 2007). "
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    • "The engagement of frontal regions has been documented in children as young as 4–6 years of age (4) and the maturation of the circuit (including the basal ganglia and the parietal lobe) extends through adolescence (3, 5). This multi-node attention network (6) includes executive regions of the frontal lobe (the dorsal prefrontal cortex and the dorsal anterior cingulate), regions such as the basal ganglia (including the caudate and the putamen) that presumably play central roles in relaying information between and linking signals across brain networks (7, 8), and the parietal lobe that is essential for mechanisms of spatial orientation (9). The ascent of attention competence in adolescence corresponds with linear progression in the development of and anatomical connectivity between these key brain structures in the attention network (10, 11). "
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