Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH et al.. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86, 899-906

Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA.
American Journal of Clinical Nutrition (Impact Factor: 6.77). 11/2007; 86(4):899-906.
Source: PubMed


Currently, we are experiencing an epidemic of cardiorenal disease characterized by increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney disease. Whereas excessive caloric intake and physical inactivity are likely important factors driving the obesity epidemic, it is important to consider additional mechanisms. We revisit an old hypothesis that sugar, particularly excessive fructose intake, has a critical role in the epidemic of cardiorenal disease. We also present evidence that the unique ability of fructose to induce an increase in uric acid may be a major mechanism by which fructose can cause cardiorenal disease. Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis.

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Available from: Laura Gabriela Sánchez-Lozada
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    • "Because of the increase in using high fructose syrup, the consumption of fructose has been increased markedly in the last few centuries [11]. Also, studies have demonstrated that consumption of high fructose diets results in fatty liver, hyperlipidemia , and insulin resistance [12] [13]. Therefore, the current study was designed to investigate the antihyperglycemic , anti-hyperlipidemic and insulin sensitizing effects of P. pavonia extract in an established model of T2DM characterized by insulin resistance. "
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    ABSTRACT: The current study was designed to investigate the anti-diabetic effects of the brown seaweed Padina pavonia in fructose-induced diabetic rats. The experimental rats were fed with fructose solution (30%) in drinking water for 30 days. Rats exhibited hyperglycemia and hyperinsulinemia were selected and divided into four groups as following; negative control, positive control and the other groups were orally supplemented with 50 and 100 mg/kg body weight P. pavonia extract for 30 days, respectively. At the end of the experimental period, blood and liver samples were collected for subsequent bioassays. Fructose supplementation produced significant increase in circulating fasting and postprandial glucose, insulin, lipids and pro-inflammatory cytokines along with decreased adiponectin levels. In addition, fructose-induced rats exhibited significantly increased levels of liver lipid peroxidation and nitric oxide, and declined glutathione content and activity of superoxide dismutase and glutathione peroxidase. Supplementation of either dose of P. pavonia markedly alleviated these alterations and improved the metabolic profile. The results revealed that P. pavonia was effective in improving insulin sensitivity and attenuating metabolic disturbances, inflammation and oxidative stress in fructose-induced diabetic rats. In conclusion, the tested brown seaweed seemed to have a promising value for the treatment of type 2 diabetes mellitus (T2DM).
    Full-text · Article · Dec 2015
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    • "Based on our research and theorizing, connecting a fast-food meal with spoonfuls of lard may help to reduce preference for these unhealthy, fatty meals. In terms of practical advancements, some studies indicate that the over-consumption of SSBs may pose a serious public-health threat (Belpoggi et al., 2006; Johnson et al., 2007; Ludwig et al., 2001; Schulze et al., 2004; but see Forshee et al., 2008; Gibson, 2008 "

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    • "The IFBT seed residues from extraction of biofuels could be used as biofertilisers to improve the soil nutrient status, improving crop yield thus contributing to household food security. Artificial sweeteners have been linked to the development of systemic health problems (Johnson et al., 2007) hence the preference and drive for the use of natural sugars in foods. The fruit of indigenous trees is a potential source of natural sugars. "

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