Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology

School of Electrical & Computer Engineering, Purdue University, West Lafayette, IN 47907-2035, USA.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 02/2006; 1:5033-6. DOI: 10.1109/IEMBS.2006.259570
Source: PubMed


Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.

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Available from: Vijay A Ramchandani, Aug 22, 2014
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