Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging

Department of Radiology, The University of Virginia, 409 Lane Road, MR4 Building 1192, PO Box 801339, Charlottesville, VA 22908, USA.
Bioorganic & medicinal chemistry letters (Impact Factor: 2.42). 01/2008; 17(24):6876-8. DOI: 10.1016/j.bmcl.2007.10.013
Source: PubMed


A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After (64)Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.

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