The "Sunshine Vitamin": Benefits Beyond Bone?

Tufts University, Бостон, Georgia, United States
Journal of the National Cancer Institute (Impact Factor: 12.58). 12/2007; 99(21):1563-5. DOI: 10.1093/jnci/djm211
Source: PubMed
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Available from: Johanna T Dwyer
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    • "Vitamin D not only regulates bone metabolism, but also has an important role in adipogenesis and in diseases such as diabetes, and cancer (Mathieu and Badenhhjoop, 2005 and Davis and Dwyer, 2007). The main source of vitamin D is by production through solar Ultraviolet B (UVB) radiation (280–315nm) that penetratesthe skin 7- dehydrocholesterol, which is locatedin the epidermal layer of the skin, is converted topre-vitamin D 3 , which is then rapidly converted to vitamin D 3 (Davis and Dwyer, 2007). Vitamin D 3 can also be foundin a few Nature and Science 2014;12(1) "
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    ABSTRACT: Low concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are common among adults, particularly those diagnosed as overweight or obese. Female Saudi Arabian residents are at risk of developing vitamin D insufficiency related to cultural practices that reduce exposure to Ultraviolet B (UVB) radiation. During the past 10 years, there has been a dramatic increase in obesity and overweight over time in the Kingdom of Saudi Arabia (KSA) and the rates remain high. The objective of this study is to examine whether current weight and weight change since 18 years can alter vitamin D status among healthy Saudi women. We hypothesized that serum 25(OH) D is significantly higher in women who maintained stable weight over time than in those who gained weight. We conducted this study among 120 healthy women with a mean age 47.9 years; range (18–75) years, and a mean body mass index (BMI) of 29.7 kg/m 2 . Height, weight, serum 25(OH)D concentrations, and questionnaires about medical history, health behaviors were measured. Results reported that approximately 89% of women were 25(OH)D deficient (≤ 10 ng/mL), and 11% were sufficient (≥ 20 ng/mL). The adjusted logistic regression model shows no relationship between BMI and serum 25(OH) D. The odds ratios (CI 95%) are 0.69 (0.19, 2.5) and 3.99 (0.90, 17.6) for the overweight and obese categories, respectively. Our results suggest that neither current weight noradult weight were associated with vitamin D status in Saudi Arabian women. This lack of association is likely related to the high prevalence of deficiency at all weight classifications. Saudi Arabian women may represent a specific subgroup at high risk for deficient vitamin D status.
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    ABSTRACT: Heliotherapien durch die selektive Ausschaltung riskanter UV-A-/UV-B-Strahlungsbereiche sowie die Reduktion von IR-Strahlung bieten neue Möglichkeiten in der phototherapeutischen Behandlung vieler Hautkrankheiten. Zugleich können sie begleitend bei diversen Allgemeinerkrankungen mit Konnex zu Vitamin-D-Mangel und/oder Sonnenlichtmangel eingesetzt werden. Der Artikel schildert ein aktuelles Klinik-Projekt zum Thema in Dubai.
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    ABSTRACT: Accumulating evidence suggests that vitamin D may protect against cancer, but results from epidemiologic studies are inconclusive so far, and other studies looking into the prospective association of total cancer mortality and serum 25-hydroxyvitamin D [25(OH)D] levels, which are considered to be the best indicator of vitamin D status, are scarce. We measured 25(OH)D and 1,25-dihydroxyvitamin D in 3,299 patients from the Ludwigshafen Risk and Cardiovascular Health study. The baseline examination was done between July 1997 and January 2000 and included a fasting blood sampling in the morning before coronary angiography. During a median follow-up period of 7.75 years, 95 patients died due to cancer. After adjustment for possible confounders, the Cox proportional hazard ratio (95% confidence interval) of the fourth 25(OH)D quartile was 0.45 (0.22-0.93) when compared with the first quartile and the hazard ratio per increase of 25 nmol/L in serum 25(OH)D concentrations was 0.66 (0.49-0.89). We found no association between serum 1,25-dihydroxyvitamin D levels and fatal cancer. In summary, our data suggest that low levels of 25(OH)D are associated with increased risk of fatal cancer in patients referred to coronary angiography and that the maintenance of a sufficient vitamin D status might therefore be a promising approach for the prevention and/or treatment of cancer.
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