Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR

GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Bioorganic & medicinal chemistry letters (Impact Factor: 2.42). 02/2008; 18(1):324-8. DOI: 10.1016/j.bmcl.2007.10.043
Source: PubMed


The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.

7 Reads
Show more