Article

MEROPS: the peptidase database

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Nucleic Acids Research (Impact Factor: 9.11). 02/2008; 36(Database issue):D320-5. DOI: 10.1093/nar/gkm954
Source: PubMed

ABSTRACT

Peptidases (proteolytic enzymes or proteases), their substrates and inhibitors are of great relevance to biology, medicine
and biotechnology. The MEROPS database (http://merops.sanger.ac.uk) aims to fulfil the need for an integrated source of information about these. The organizational principle of the database
is a hierarchical classification in which homologous sets of peptidases and protein inhibitors are grouped into protein species,
which are grouped into families and in turn grouped into clans. Important additions to the database include newly written,
concise text annotations for peptidase clans and the small molecule inhibitors that are outside the scope of the standard
classification; displays to show peptidase specificity compiled from our collection of known substrate cleavages; tables of
peptidase–inhibitor interactions; and dynamically generated alignments of representatives of each protein species at the family
level. New ways to compare peptidase and inhibitor complements between any two organisms whose genomes have been completely
sequenced, or between different strains or subspecies of the same organism, have been devised.

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    • "BRENDA (Chang, Scheer, Grote, Schomburg, & Schomburg, 2009) at http://www.brenda-enzymes.org/and using the MEROPS database (Rawlings & Barrett, 1999;Rawlings, Morton, Kok, Kong, & Barrett, 2008) at http://merops.sanger.ac.uk/. The cleavage specificity of the thermolysin enzyme was analysed using peptide cutter http://expasy.org/tools/peptidecutter and the BIOPEP database (Minkiewicz, Dziuba, Iwaniak, Dziuba, & Darewicz, 2008) at http://www.uwm.edu.pl/biochemia. "
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