Intralesional steroid injection for proliferative parotid hemangiomas

Vascular Anomalies Center, University of Arkansas for Medical Sciences, Arkansas, Children's Hospital, Little Rock, AR, USA.
International Journal of Pediatric Otorhinolaryngology (Impact Factor: 1.19). 02/2008; 72(1):81-7. DOI: 10.1016/j.ijporl.2007.09.024
Source: PubMed


To evaluate the efficacy of proliferative phase intralesional steroid injections in the treatment of parotid hemangiomas.
Retrospective analysis of pediatric patients with parotid hemangiomas treated with intralesional steroid injections during the proliferative phase.
Vascular Anomalies Center, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, USA.
Twenty-one pediatric patients, ages 4-39 months.
Between 2001 and 2006, 21 patients received steroid injections for 23 parotid hemangiomas (bilateral in 2 patients). A total of 1-3 injections over the first year of life were given at 6-25 week intervals.
Main outcome measures included softening, decreased growth rate, and/or decrease in size. After injection, achievement of outcome measures occurred with all lesions. No incidence of tissue atrophy or facial nerve injury was seen. Four of 21 (19%) patients developed failure to thrive (FTT).
Parotid hemangiomas can be effectively controlled with proliferative phase intralesional steroid injections. Injections may limit the need for future extensive surgery. Further prospective randomized trials are needed to support these claims. Failure to thrive may be a potential complication of intralesional steroid injection. Endocrine/growth monitoring should be considered when treating with intralesional steroids.

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    • "Each treatment option has limited therapeutic benefit with its own side-effect profile and risks (Bauman et al, 1997; Adams, 2001; Goyal et al, 2004; Deboer and Boston, 2008). Intralesional steroid therapy, often requiring multiple injections, is an effective and safe first-line option for nasal tip and deep parotid lesions in the proliferative phase to control accelerated growth and terrible esthetic consequences (Buckmiller et al, 2008; Simic et al, 2009). Massive hemangiomas, liver disease with enzyme dysfunction, airway lesions, segmental disease, and periorbital involvement often require systemic therapy to control progression and devastating functional outcomes. "
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