Lack of effects of vagus nerve stimulation on drug-resistant epilepsy in eight pediatric patients with autism spectrum disorders: A prospective 2-year follow-up study
Department of Pediatrics, Queen Silvia Children's Hospital, Göteborg, Sweden. Epilepsy & Behavior
(Impact Factor: 2.26).
03/2008; 12(2):298-304. DOI: 10.1016/j.yebeh.2007.10.007
Vagus nerve stimulation (VNS) therapy has been reported to reduce seizure frequency in some children with drug-resistant epilepsy who are not suitable candidates for epilepsy surgery. It has been suggested that there may be positive cognitive and/or behavioral effects independent of seizure control. We describe the effects of VNS with respect to seizure frequency, cognition, and autistic symptoms and behavior in eight children and adolescents with medically intractable epilepsy and autism. In comparison to baseline, seizure frequency had not decreased in anyone in our series at the 2-year follow-up. In three cases, minor improvements in general functioning were noted, but there were no positive cognitive effects. This open prospective pilot study highlights the need for more prospective studies to prevent false expectations of improvement in this severely disabled group.
Available from: Bertil Rydenhag
- "Global assessment of psychosocial functioning has been used in intervention studies as a clinically meaningful measure incorporating several aspects of functioning . Global assessment scales, such as the Children's Global Assessment Scale (CGAS), have been used in studies not only of psychiatric disorders , but also of physical disorders    . "
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ABSTRACT: This is a prospective study of a consecutive series of children undergoing epilepsy surgery. The main aims were to evaluate the heterogeneity with respect to psychopathology and IQ, and to use a global assessment scale (Children’s Global Assessment Scale [CGAS]) to evaluate psychosocial functioning. Clinical neuropsychiatric and neuropsychological assessments were made at baseline and at the 2-year follow-up in 24 patients, and changes were analyzed at an individual level. Psychiatric disorders (mainly attention deficit hyperactivity disorder and/or autism spectrum disorders) were found in 17 of 24 at some point. All except one child with psychiatric diagnoses before surgery still had at least one diagnosis at follow-up. Intellectual ability remained stable in the majority of cases, both in individuals with and in individuals without mental retardation. The CGAS illustrated the consequences of the extensive comorbidity in this cohort. The behavioral problems had been undiagnosed despite parental concern in many cases, indicating an unrecognized need for services for children with drug-resistant epilepsy.
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ABSTRACT: Patients with cancer often feel that they can improve their physical condition and prognosis by altering what they eat. Their quest for nutritional information may lead them to alternative and complementary dietary therapies. Although many of thesetherapies appear to be "nontoxic" or "natural" they are often restrictive and place patients at risk for various complications and adverse events. Weitzman (1998) adds that prospective, randomized trials of alternative and complementary dietary therapies are needed, and that these nutritional therapies must be used with great caution by pediatric patients because this population is at high risk for nutritional deficiencies and diet-related complications.
Available from: Susanna Danielsson
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ABSTRACT: Epilepsy is much more common in individuals with autism than in the general population. The extent to which epilepsy influences the outcome of autism is poorly understood. Many children with medically intractable epilepsy have neurodevelopmental disorders, including autism. The objective of this study was to gain further insight into the co-occurrence of epilepsy and autism. In a population-based follow-up study of 120 individuals with autism diagnosed in childhood, 108 were reassessed at ages 17-40 years. The majority had autism and mental retardation (MR). The carers of 42/43 with a history of epilepsy were interviewed, and medical charts were reviewed. Epilepsy onset was most common in the first years of life but also occurred in adults. Partial seizures dominated and seizure frequency had a great impact on the individuals' lives. Epilepsy remitted in 16%. Severe MR and autism were significantly associated with epilepsy, especially in females. The cognitive level and the adaptive behaviour level were significantly lower in the epilepsy group than in the non- epilepsy group. The medical charts of 16 children undergoing temporal lobe resections were reviewed and the histopathological specimens were re-evaluated. Psychopathology was found in 12. Five had autism before and after surgery, one of whom became seizure free, and in three there was a positive behavioural change. Malformations of cortical development were associated with worse seizure outcome and were more common in children with psychopathology. A neuropsychiatric examination and assessments of psychosocial functioning and IQ were performed at baseline and at 2-year follow-up to assess individual outcome in (i) 25 children undergoing epilepsy surgery, and in (ii) eight children with autism and intractable epilepsy treated with vagus nerve stimulation (VNS). In study (i) psychopathology (mainly autism and ADHD) was present in 17 of the children at some point and contributed in a major way to the psychosocial dysfunction in affected children. Among the children with preoperative psychopathology, one was without a diagnosis after surgery. The IQ level before surgery predicted the IQ level after surgery in most cases. Seven had autism before and after surgery, and the parents reported a positive behavioural change in six. Psychosocial functioning was mainly stable in autism, except in one child who became seizure free and improved in psychosocial functioning and in one child who deteriorated. In study (ii) no one had a reduced seizure frequency after two years of VNS, autism remained and changes concerning intellectual abilities and psychosocial functioning were minor in most subjects. The parents of three children reported a positive change in social interactive abilities, and those of one child reported a negative change. In conclusion, the follow-up study of young adults with autism showed high rates of epilepsy, poor prognosis, and low remission rates. Neuropsychiatric disorders were common at baseline and two years after epilepsy surgery. A diagnosis of autism in children with intractable epilepsy remained after surgical intervention. Symptomatic improvement is not always the same as functional improvement. The main aim of epilepsy surgery is seizure control, regardless of whether or not there is co-existing psychopathology.
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