Treatment of Catatonia With Olanzapine and Amantadine

Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia, United States
Psychosomatics (Impact Factor: 1.86). 11/2007; 48(6):534-6. DOI: 10.1176/appi.psy.48.6.534
Source: PubMed


Catatonia is a disorder characterized by mutism, posturing, echophenomena, and negativism. The preferred treatment for non-malignant catatonia is benzodiazepines, which often produce a reduction in symptoms within 24 hours. Presented here is a case report of a 19-year-old woman appearing in a catatonic state that did not respond to lorazepam. On the basis of emerging evidence that atypical antipsychotics and weak N-Methyl-D-Aspartate (NMDA) receptor-antagonists may effectively treat catatonia, we treated our patient with olanzapine and amantadine, which resulted in a dramatic reduction in her catatonic symptoms.

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