Vitamin D 2 Is as Effective as Vitamin D 3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D

Department of Medicine, Boston University School of Medicine, 715 Albany Street, M-1013, Boston, Massachusetts 02118, USA.
Journal of Clinical Endocrinology & Metabolism (Impact Factor: 6.21). 04/2008; 93(3):677-81. DOI: 10.1210/jc.2007-2308
Source: PubMed


Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status.
Our objective was to determine whether vitamin D2 was less effective than vitamin D3 in maintaining serum 25-hydroxyvitamin D levels or increased the catabolism of 25-hydroxyvitamin D3.
This was a randomized, placebo-controlled, double-blinded study of healthy adults ages 18-84 yr who received placebo, 1000 IU vitamin D3, 1000 IU vitamin D2, or 500 IU vitamin D2 plus 500 IU vitamin D3 daily for 11 wk at the end of the winter.
Sixty percent of the healthy adults were vitamin D deficient at the start of the study. The circulating levels of 25-hydroxyvitamin D (mean+/-sd) increased to the same extent in the groups that received 1000 IU daily as vitamin D2 (baseline 16.9+/-10.5 ng/ml; 11 wk 26.8+/-9.6 ng/ml), vitamin D3 (baseline 19.6+/-11.1 ng/ml; 11 wk 28.9+/-11.0 ng/ml), or a combination of 500 IU vitamin D2 and 500 IU vitamin D3 (baseline 20.2+/-10.4 ng/ml; 11 wk 28.4+/-7.7 ng/ml). The 25-hydroxyvitamin D3 levels did not change in the group that received 1000 IU vitamin D2 daily. The 1000 IU dose of vitamin D2 or vitamin D3 did not raise 25-hydroxyvitamin D levels in vitamin D-deficient subjects above 30 ng/ml.
A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.

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Available from: Tai C Chen, Jan 25, 2016
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    • "In further analyses, we examined the exposure as a binary variable describing an increase in 25(OH)D of !10 ng/mL during the year leading to hospitalization. We chose the !10 ng/mL based on studies by others that show that serum 25(OH)D levels increase by 10 ng/ml over 4 weeks for patients on daily 1000 IU vitamin D 3 [23] and our prior work showing differential outcomes with 25(OH)D levels categorized as <10 ng/mL, 10e19.9 ng/mL, 20e29.9 "
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    • "Therefore, it was not surprising that vitamin D3 has been reported to be superior to vitamin D2 in terms of bioavailability and maintaining the vitamin D status by the majority of studies (Trang et al., 1998; Armas et al., 2004; Romagnoli et al., 2008; Glendenning et al., 2009; Heaney et al., 2011; Lehmann et al., 2013). Only one study reported that the two vitamers were essentially equipotent (Holick et al., 2008). "
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    • "The same dose of vitamin D 2 was as effective as vitamin D 3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxy vitamin D 3 levels. Therefore, vitamin D 2 is equally as effective as vitamin D 3 in maintaining 25-hydroxyvitamin D status (Holick et al., 2008). Vitamin D deficiency has long been known to cause rickets (Rajakumar, 2003), but inadequate levels of vitamin D has more recently been implicated in a wide variety of diseases (Bischoff-Ferrari , Giovannucci, Willett, Dietrich, & Dowson-Hughes, 2006), including some types of cancer (Garland, Gorham, Mohr, & Garland, 2009; Mohr, 2009), cardiovascular disease (Holick, 2004; Zittermann, 2006), diabetes, multiple sclerosis, and others (Gesek & Desmond, 2008; Janssens et al., 2009; Pappa, Bern, Kamin, & Grand, 2008; Shoenfeld, Amital, & Shoenfeld, 2009). "
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