A Relationship of Sex Hormone Levels and Erectile Dysfunction: Which Tests Should Be Done Routinely?

Department of Urology, Celal Bayar University, Medical Faculty, 45010 Manisa, Turkey.
Yonsei Medical Journal (Impact Factor: 1.29). 12/2007; 48(6):1015-9. DOI: 10.3349/ymj.2007.48.6.1015
Source: PubMed


In this study, the relationship between sex hormone levels and erectile dysfunction (ED), as well as the necessity of routinely measuring sex hormone levels were evaluated.
This study included one hundred patients admitted to a urology clinic for sexual dysfunction. To determine the hormone levels, following the history (included IIEF-5 score) and physical examination, triple blood samples were collected at intervals of 15 minutes between 08:00 and 10:00 am. Total and free testosterone, prolactin, follicle stimulating hormone and luteinizing hormone levels were studied.
Mean age was 43 (23-80) years. IIEF-5 score was less than 21 [9.8-4.3 (3-19)] in all study groups. There was a statistically significant correlation between tT and FSH, as well as between LH and FSH in Pearson (r =-0.513, p < 0.001, respectively) and also in Spearman tests (r=-0.224, p=0.042 and r=-0.459, p < 0.001, respectively). However, there was no correlation between age and serum hormone levels (p > 0.05). Of the 100 patients, 18 (18%) had low tT, 77 (77%) had normal and 5 (5%) had high tT levels. No statistically significant correlation was found between decreased libido and tT levels (p > 0.05). Twelve (66.6%) of the 18 patients with low tT had normal libido.
Analyzing the medical history in detail and performing a thorough physical examination can reduce the need for excessive studies and consultations, and enables patients to save time and costs.

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    • "In the last several years various studies have also underlined a role of sex hormones in ED. From them it is obvious that androgens are important for the penis growth and for its erectile regulation (Müezzinoğu et al. 2007; Traish et al. 2007), but in fact no significant correlation was ascertained between serum testosterone levels and ED, while a relationship was found between serum testosterone and FSH as well as between serum FSH and LH in patients with ED (Müezzinoğu et al. 2007). In contrast to the male patients, women with MTHFR 677CC genotype showed higher serum estradiol levels than heterozygous or homozygous carriers of the 677T allele (Thaler et al. 2006) and recurrent pregnancy loss (Ozdemir et al. 2012; Wu et al. 2012). "
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