Article

Does long-term unilateral deafness change auditory evoked potential asymmetries?

Medical Research Council, Institute of Hearing Research, Royal South Hants Hospital, Southampton SO14 OYG, United Kingdom.
Clinical Neurophysiology (Impact Factor: 3.1). 04/2008; 119(3):576-86. DOI: 10.1016/j.clinph.2007.11.010
Source: PubMed

ABSTRACT

To investigate the long-term cortical changes in auditory evoked potential (AEP) asymmetries associated with profound unilateral deafness.
Electroencephalographic (EEG) recordings from 68 channels were used to measure auditory cortex responses to monaural stimulation from 7 unilaterally deaf patients and 7 audiogram-matched controls. Source localization of the AEP N100 response was carried out and regional source waveform amplitude and latency asymmetries were analysed for activity in the N100 latency range and for the middle latency response (MLR) range.
Asymmetry indices (contralateral-ipsilateral)/(contralateral+ipsilateral) showed that matched control subjects, like normally hearing participants, produced activity in the N100 latency range that was more contralaterally dominant for left compared to right ear stimulation. Contrary to expectation, source waveforms and asymmetry indices in the MLR and N100 latency range were similar for unilaterally deaf patients, their matched controls and a group of normally hearing participants.
Regional source waveform analysis revealed no evidence of systematic cortical changes in hemispheric asymmetries associated with long-term unilateral deafness. It is possible that a reorganization of cortical asymmetries to a 'normal' pattern had taken place in the years between deafness and testing.
Electrophysiological measures of auditory hemispheric asymmetries do not suggest long-term cortical reorganisation as a result of profound unilateral deafness.

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    • " . Significant increases in responses recorded over the ipsilateral hemisphere were found in Pon - ton et al . , 2001 and significant increases in dipoles located in both auditory cortices from EEG in Maslin et al . , 2013 . On the other hand , limited effects were found in several other stud - ies [ Vasama et al . , 1995 ; Fujiki et al . , 1998 ; Hine et al . , 2008 ; Hanss et al . , 2009 ] . One study of childhood unilateral deaf - ness also showed minimal effects , perhaps for similar reasons [ Vasama and Makela , 1994 ] . Although the aural preference could not be assessed in the present study because of the highly abnormal responses with very large underlying dipoles evoked in the newly implant"
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    • "~biocog/content/widmann/eeglab-plugins/). For the analysis of the middle-latency components, data were filtered from 20 to 80 Hz (cf., Hine et al., 2008); for the analysis of the late event-related components we used a filter range of 0.1–40 Hz. Artifact rejection was based on independent component analysis (ICA). "
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    • "Using a symmetry constraint, the N100 global field power onset-to-peak interval was modelled and the resulting Talairach coordinates stored for each individual. To derive source waveforms, two symmetric equivalent current dipoles were seeded into superior temporal lobes [Talairach coordinates (x, y, z) = AE 49.5, À17, 9; see also (Hine and Debener, 2007;Debener et al., 2008;Hine et al., 2008)]. The adequacy of this location for source waveform analysis was evaluated by determining the Euclidean distance between the free, symmetric source model and this reference location. "
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