Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: A meta-analysis

Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital (RWTH), Aachen, Germany.
Journal Of Clinical Periodontology (Impact Factor: 4.01). 04/2008; 35(3):183-92. DOI: 10.1111/j.1600-051X.2007.01189.x
Source: PubMed


Multiple studies have reported associations between periodontitis and particular human leukocyte antigens (HLA). Because associations are inconsistent, we conducted a systematic literature review and a meta-analysis focusing on Caucasian case-control studies.
A literature search reporting on the distribution of HLA class I and II phenotypes in Caucasian patients with chronic periodontitis (CP) and aggressive periodontitis (AP) was performed. Data sources included electronic databases and bibliographies of published articles. Screening and data abstraction were conducted independently by different reviewers.
Out of 174 publications, 12 studies were considered to be suitable for meta-analysis. In patients with CP, no significant HLA associations were found. Patients with AP showed a positive association with HLA-A9 [odds ratio=2.59 (95% confidence interval 1.36-4.83), p=0.004] and HLA-B15 [1.90 (1.15-3.16), p=0.01] as well as a negative association with HLA-A2 [0.72 (0.56-0.94), p=0.01] and -B5 [0.49 (0.30-0.79), p=0.004]. On grouping all patients into one periodontitis group (AP+CP), the same deviations were confirmed with higher statistical significance. For HLA-A9 and -B15, significant heterogeneity was found between the studies. No significant associations were found with HLA class II antigens.
HLA-A9 and -B15 seem to represent susceptibility factors for AP whereas HLA-A2 and -B5 are potential protective factors against periodontitis among Caucasians.

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Available from: Jamal M. Stein, Sep 07, 2014
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    • "Thus, our results indicate a protective role of HLA-A * 02. A2 could yield an efficient antimicrobial T-cell response reducing the disease [25]. Otherwise, HLA-B * 40 was more frequent in both groups representing a risk effect against CP, although significance was also lost after Bonferroni correction. "
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    • "linkage disequilibrium seemed to exist between associated alleles. The positive association of HLA-A9 and HLA-B15 with AP in Caucasians [10] [12] [13] but not in Lebanese is also probably accounted for by the ethnic differences between the two populations. In addition, HLADRB1*13 seemed to have a more frequent occurrence in patients with AP that are Germans of Caucasian descent [26] and HLA-B*15 was also found to be associated with AP in Indian population [27]. "
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