Article

Equine Protozoal Myeloencephalitis Associated with Neosporosis in 3 Horses

Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616 2007, USA.
Journal of Veterinary Internal Medicine (Impact Factor: 1.88). 11/2007; 21(6):1405-8. DOI: 10.1892/07-054.1
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    • "The definitive host of N. hughesi is still unknown (Hoane et al., 2006). Abortion and neonatal diseases are associated with N. caninum infection in horses (Villalobos et al., 2006;Kligler et al., 2007) whereas N. hughesi infection is associated with neurological diseases, principally equine protozoal myeloencephalitis (EPM) (Finno et al., 2007;Kligler et al., 2007). In Brazil, the seroprevalence of Neospora spp. "
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    ABSTRACT: Sera from 112 mares from 5 horse-breeding farms was examined for the presence of antibodies to N. caninum and T. gondii by an indirect fluorescent antibody test (IFAT), as well as from dogs and cattle present on these properties for the presence of antibodies to N. caninum. Among the 112 mares, 35 had a history of reproductive problems in the last breeding season and 77 had no reproductive problems. The rates of seroprevalence of N. caninum in mares with and without a history of reproductive problems were 25.71% and 6.49% and from T. gondii 2.85% and 1.29%, respectively. In dogs and cattle, the rates of seroprevalence of N. caninum were 10.52% and 15.55%, respectively. A positive correlation was found between the presence of antibodies against N. caninum (p = 0.010) in mares and the occurrence of reproductive problems using the Fisher's Exact Test. Significantly higher seroprevalence for N. caninum in mares was observed on the farm that had seropositive dogs (p = 0.018). Cattle on this farm were also seropositive. No significant differences in seropositivity were found on farms where dogs were seronegative, or absent. This result suggests, for the first time, the presence of seropositive dogs as a risk factor for N. caninum in mares and the necessity for further investigation of the epidemiology of this parasite in horse-breeding farms with reproductive problems and the presence of cattle and dogs. This is the first report on the occurrence of antibodies against N. caninum in horses from the state of Santa Catarina, Brazil.
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    ABSTRACT: RESUMO Dentre as enfermidades neurológicas que acometem os equinos, a mieloencefalite protozoária equina (EPM) encontra-se em posição de destaque. Levando em consideração a importância da EPM no contexto das doenças neurológicas, esta revisão aborda entre outros, os aspectos epidemiológicos, clínicos, diagnósticos e terapêuticos da EPM, causadas tanto pelo Sarcocystis neurona quanto pelo Neospora caninum e Neospora hughesi, cujo objetivo é contribuir para a atualização dos profissionais envolvidos na área de clínica médica de equinos. ABSTRACT Among the neurological disorders that affect the horses, the equine protozoal myeloencephalitis (EPM) is the most important. Considering the importance of EPM in the context of neurological diseases, this review covers among others, the epidemiological, clinical, diagnoses and treatment of EPM, caused by Sarcocystis neurona as by Neospora caninum and Neospora hughesi and this study aims at contributing for the update of the veterinarians involved with equine internal medicine.
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    ABSTRACT: A protozoal parasite identified as Neospora hughesi was found in inflammatory lesions in the central nervous system of a Canadian-born adult horse presented with neurological signs. This is believed to be the first case of equine protozoal myeloencephalitis (EPM) caused by Neospora hughesi in a horse outside of the United States.
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