Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents

Department of Chemisry IFM and Molecular Imaging Center, University of Torino, Via P. Giuria 7, I-10125, Torino, Italy.
Chemical Communications (Impact Factor: 6.83). 03/2008; 5(5):600-2. DOI: 10.1039/b715383j
Source: PubMed


Improved LIPOCEST MRI contrast agents with highly shifted intraliposomal water protons were prepared by entrapping neutral polynuclear Tm(III)-based paramagnetic shift reagents in phospholipidic vesicles.

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Available from: Jebasingh Bhagavathsingh, Jul 14, 2015
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    • "Paramagnetic CEST agents are ideally suited for molecular imaging applications because one can switch the contrast on and off as desired simply by adjusting the pulse sequence parameters. Liposome-based CEST agents have shown great sensitivity and potential for molecular MRI.70 "
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