Drosophila innate immunity and response to fungal infections

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.
Cellular Microbiology (Impact Factor: 4.92). 06/2008; 10(5):1021-6. DOI: 10.1111/j.1462-5822.2008.01120.x
Source: PubMed


The fruit fly Drosophila melanogaster is an important model for the analysis of the interaction between host immune systems and fungal pathogens. Recent experiments have extended our understanding of the Toll-based signalling pathway critical to response to fungal infections, and identified new elements involved in cellular and humoral-based defences. The fly immune system shows remarkable sophistication in its ability to discriminate among pathogens, and the powerful genetics available to researchers studying the adult fly response, and the ability to manipulate cultured phagocytic cell lines with RNAi, are allowing researchers to dissect the molecular details of the process.

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Available from: Malcolm Whiteway, Oct 13, 2014
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    • "identity) of yeast PMT4 O-mannosyltransferase involved in protein O-mannosylation/glycosylation and determining the structure and integrity of fungal cell walls (Lengeler et al., 2008). It is well-known that fungal cell wall components (mainly the glucans) are the primary pathogenassociated molecular patterns that trigger insect Toll pathway to induce immune responses (Gottar et al., 2006; Levitin and Whiteway, 2008).Thus, upregulation of these genes, if not all, in ΔMrpacC could lead to mutant cell wall remodelling that in turn would trigger stronger insect immune responses. Thus, it could be concluded that MrpacC contributes to fungal virulence by maintaining cell wall integrity/remodelling in insect haemocoels. "
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    • "There have been many reports on AMPs from various insect species, but very few reviews on insect AMPs (Imler and Bulet 2005; Li et al. 2006). Several reviews related to insect AMPs are mainly from Drosophila with a focus on activation of AMPs in response to various infections or regulation of AMP gene expressions by the Toll and IMD signaling pathways (Fullaondo and Lee 2012; Hetru and Hoffmann 2009; Lazzaro 2008; Lemaitre and Hoffmann 2007; Levitin and Whiteway 2008; Moy and Cherry 2013). Antiparasitic peptides and antimalarial peptides have been reviewed recently (Bell 2011; Pretzel et al. 2013). "
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