Alcohol Consumption and the Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Centre for Eye Research Australia, The University of Melbourne, Victoria, Australia.
American Journal of Ophthalmology (Impact Factor: 3.87). 05/2008; 145(4):707-715. DOI: 10.1016/j.ajo.2007.12.005
Source: PubMed


To review systematically the evidence currently available on alcohol consumption and the risk of age-related macular degeneration (AMD).
Systematic review and meta-analysis of observational studies.
Seven databases were searched systematically with no limits on the year or language of publication for prospective cohort studies. References identified from pertinent reviews and articles also were retrieved. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. These criteria included appropriate adjustment for age and smoking in the analysis. Of the 441 studies identified initially, five cohort studies met the selection criteria. Data extraction and study quality evaluation were performed independently by two reviewers and results were pooled quantitatively using meta-analytic methods.
The five cohort studies included 136,946 people, among whom AMD developed in 1923 (1,513 early and 410 late). Pooled results showed that heavy alcohol consumption was associated with an increased risk of early AMD (pooled odds ratio, 1.47; 95% confidence interval, 1.10 to 1.95), whereas the association between heavy alcohol consumption and risk of late AMD was inconclusive. There were insufficient data to evaluate a dose-response association between alcohol consumption and AMD or the association between moderate alcohol consumption and AMD.
Heavy alcohol consumption (more than three standard drinks per day) is associated with an increased risk of early AMD. Although this association seems to be independent of smoking, residual confounding effects from smoking cannot be excluded completely.

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Available from: Elaine W Chong
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    • "Moderate alcohol consumption is a protective factor in cardiovascular disease [22] and has been suggested to be protective for AMD [23], while heavy alcohol consumption has been associated with an increased risk of AMD [24]. The current study results support the beneficial effect of regular alcohol consumption on cardiovascular disease (lower mean BMI, slightly elevated HDLC, and decreased total triglyceride levels). "
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    • "In the African region, it is estimated that about 2.4% of deaths and 2.1% of DALYs lost are attributed to alcohol use and AUD (Rehm et al. 2009). Adverse effects of alcohol use include increased risk of infectious diseases such as HIV/AIDS and TB, and chronic non-communicable diseases (NCD) (Makimoto & Higuchi 1999; Horn-Ross et al. 2004; WHO 2004; Ahmed et al. 2006; Chen et al. 2008; Chong et al. 2008; Brooks et al. 2009; Genkinger et al. 2009; Brandish & Sheron 2010; Kahl et al. 2010; Patra et al. 2010; Stroffolini et al. 2010), as well as intentional and unintentional injuries, and social problems such as domestic violence, unemployment and decreased work productivity (Gmel & Rehm 2003; Fisher et al. 2007; Kalichman et al. 2007; Rehm et al. 2009; Zaleski et al. 2010; Abbey 2011; Aldridge-Gerry et al. 2011). "
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