Ringwood L, Li L. The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation. Cytokine 42: 1-7
The Laboratory of Innate Immunity and Inflammation, Department of Biological Sciences, West Campus Drive, Fralin Biotechnology Center, Virginia Tech, Blacksburg, VA 24061, USA.Cytokine (Impact Factor: 2.66). 05/2008; 42(1):1-7. DOI: 10.1016/j.cyto.2007.12.012
Innate immunity and inflammation plays a key role in host defense and wound healing. However, Excessive or altered inflammatory processes can contribute to severe and diverse human diseases including cardiovascular disease, diabetes and cancer. The interleukin-1 receptor-associated kinases (IRAKs) are critically involved in the regulation of intracellular signaling networks controlling inflammation. Collective studies indicate that IRAKs are present in many cell types, and can mediate signals from various cell receptors including toll-like-receptors (TLRs). Consequently, diverse downstream signaling processes can be elicited following the activation of various IRAKs. Given the critical and complex roles IRAK proteins play, it is not surprising that genetic variations in human IRAK genes have been found to be linked with various human inflammatory diseases. This review intends to summarize the recent advances regarding the regulations of various IRAK proteins and their cellular functions in mediating inflammatory signaling processes.
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- "TLR/IL-1R receptors associate with MyD88 through homotypic interactions between their respective TIR domain. This interaction then allows MyD88 to recruit members of the interleukin-1 receptor-associated kinase (IRAK) family (IRAK1, IRAK2, and IRAK4) through homotypic interactions between their respective Death Domains (DDs)  "
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