Glucocorticoid Corticosteroids for Duchenne Muscular Dystrophy (Review)
Glucocorticoid corticosteroid therapy in Duchenne dystrophy improves muscle strength and function for six months to two years Duchenne muscular dystrophy is an incurable disease of childhood. Muscle wasting and loss of ability to walk lead to wheelchair dependence and eventually death. The precise way that glucocorticoids increase strength is unknown. Randomised controlled trials showed that glucocorticoid corticosteroids improved muscle strength and function for six months to two years. Short-term side effects were significant but not severe and could be managed. The long-term benefit remains unclear and has to be weighed against the long-term side effects of these drugs. Whether long-term trials to address this uncertainty are desirable should be addressed from ethical and parental perspectives.