Origins and Fates of Cardiovascular Progenitor Cells

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Cell (Impact Factor: 32.24). 03/2008; 132(4):537-43. DOI: 10.1016/j.cell.2008.02.002
Source: PubMed


Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations appear to be distinct. Elucidating the origins and lineage relationships of these cell populations will accelerate clinical applications such as drug screening and cell therapy as well as shedding light on the pathogenic mechanisms underlying cardiac diseases.

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Available from: Sean M Wu
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    • "Cardiovascular progenitor cells (CPCs) are the building blocks of the heart, and have the potential to form cardiomyocytes, endocardium and smooth muscle cells (Kattman et al., 2006; Moretti et al., 2006). CPCs are among the first to migrate during gastrulation, ultimately reaching bilateral regions of the anterior lateral plate mesoderm (ALPM) (Wu et al., 2008). Fate mapping studies in multiple vertebrate models have shown that CPCs arise from a fixed location in the pregastrulation embryo (reviewed in (Evans et al., 2010)). "
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    • "Both these cells types have recently been targeted for delivery of pluripotent transgenes for the generation of induced pluripotent stem cells [10] [11]. Cardiac progenitor cells, on the other hand, comprise of an adult stem cell population that can give rise to all the cell types that recapitulate the heart [12] and therefore have a strong potential to be used for cardiac repair and regeneration following myocardial infarction. In the present study, we have tested our hypothesis that PEI-based polymer hybrids can transfect primary cells at higher efficiencies than other existing non-viral methods. "
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