Systemic lupus erythematosus. N Engl J Med

ArticleinNew England Journal of Medicine 358(9):929-39 · March 2008with15 Reads
Impact Factor: 55.87 · DOI: 10.1056/NEJMra071297 · Source: PubMed


    Pathogenic autoantibodies are the primary cause of tissue damage in patients with lupus. The production of these antibodies arises by means of complex mechanisms involving every key facet of the immune system. Many different elements of the system are potential targets for therapeutic drugs in patients with lupus.