Profile and outcome of neuroblastoma with conventional chemotherapy in children older than one year: A 15-years experience

Pediatric Hematology/Oncology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian pediatrics (Impact Factor: 1.04). 03/2008; 45(2):135-9.
Source: PubMed


The clinical profile and outcome of neuroblastoma in 103 children, older than one-year is presented. 74 had Stage IV, 27 Stage III and one patient each had Stage I or II disease. Treatment included chemotherapy followed by surgical resection/debulking. Radiotherapy was administered to those with residual tumor. Chemotherapy consisted of OPEC (vincristine, cyclophosphamide, cisplatin and etoposide). The caretakers of 54 (52.4%) children either did not opt for or defaulted therapy, whilst 3 patients died before chemotherapy could be initiated. Of the remaining 46 patients, the tumor progressed during therapy in 19 (41.3%). Relapse of disease was documented in 22 (47.8%) cases. Merely 4 (8.7%) children are disease free for a period of 16.5+/-6.7 months. Majority of children presented with advanced disease and the outcome was dismal with conventional non-myloablative chemotherapy.

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Available from: Deepak Bansal, Apr 16, 2015
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    • "A similar observation was also reported in India. Only 2 out of 101 neuroblastoma patients with stage III or IV remain disease free and in others, disease relapsed soon after completing the therapy (patients were administered courses of “OPEC” therapy, namely, vincristine 1.5 mg/m2 and cyclophosphamide 600 mg/m2 on day 1, cisplatin 60 mg/m2 on day 2 and etoposide 120 mg/m2 on day 4) indicating the negligible effect of these chemotherapeutic agents [9]. Therefore, identification and study on the development of new drugs to treat high-risk neuroblastoma are warranted. "
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