Cutaneous head and neck melanoma: The old and the new

ArticleinExpert Review of Anti-infective Therapy 8(3):403-12 · April 2008with8 Reads
DOI: 10.1586/14737140.8.3.403 · Source: PubMed
Abstract
The incidence rate of malignant melanoma has shown a rapid worldwide rise in recent years. The staging and management of head and neck melanoma presents some unique challenges. Surgery remains the cornerstone of treatment, while sentinel node biopsy is the most accurate staging modality for regional disease. The complex regional anatomy and lymphovascular drainage of this region may account for the increased biologic aggressiveness and treatment challenges of this disease. Improved understanding of the radiobiology of melanoma has resulted in new adjuvant radiotherapy approaches, yielding improved control rates. The treatment outcomes of metastatic head and neck melanoma remain disappointing but important progress has been made in the understanding of melanoma biology.
    • "Malignant melanoma affects millions of people worldwide and, considering its rapidly rising incidence and high mortality, represents a major health problem. Although surgery is effective in early melanoma stages, high resistance of melanoma cells to chemo-and radiation therapy compromises post-surgical efforts that prevent recurrence in metastatic disease (Fecher and Flaherty 2009, Rigual et al 2008, Soengas and Lowe 2003). Adjuvant therapy with a recombinant version of endogenous cytokine IFNα is one of the few FDAapproved treatments (Ascierto and Kirkwood 2008, Kaehler et al 2010, Yao et al 2009). "
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