Dam1 complexes go it alone on disassembling microtubules

ArticleinNature Cell Biology 10(4):379-81 · May 2008with6 Reads
Impact Factor: 19.68 · DOI: 10.1038/ncb0408-379 · Source: PubMed


    Kinetochores maintain a mechanical grip on disassembling microtubule plus ends, possibly through a 16-member Dam1 ring that acts as a sliding clamp. It turns out, however, that a ring is not required for maintaining grip: individual Dam1 complexes in vitro can diffuse on the microtubule lattice and track shortening microtubule tips.