Treatment of osteoarthritis with Pycnogenol®. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti-pescara University and San Valentino Vascular Screening Project, San Valentino, PE, Italy.
Phytotherapy Research (Impact Factor: 2.66). 04/2008; 22(4):518-23. DOI: 10.1002/ptr.2376
Source: PubMed
The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of 100 mg Pycnogenol daily (oral capsules) in a 3 month study in patients with osteoarthritis (OA). OA symptoms were evaluated by WOMAC scores, mobility by recording their walking performance (treadmill). Treatment (77 patients) and placebo group (79) were comparable for age, sex distribution, WOMAC scores, walking distances and use of antiinflammatory drugs. The global WOMAC score decreased by 56% (p < 0.05) in the treatment group versus 9.6% in the placebo group. Walking distance in the treadmill test was prolonged from 68 m at the start to 198 m after 3 months treatment (p < 0.05), under placebo, from 65 m to 88 m (NS). The use of drugs decreased by 58% in the treatment group (p < 0.05) versus 1% under placebo. Gastrointestinal complications decreased by 63% in the treatment group, but only 3% under placebo. Overall, treatment costs were reduced significantly compared with placebo. Foot edema was present in 76% of the patients of the treatment group at inclusion and in 79% of the controls. After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls. In conclusion, Pycnogenol offers an option for reduction of treatment costs and side effects by sparing antiinflammatory drugs.
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    • "Downregulation of 5-lipoxygenase consequently decreases leukotriene levels in asthmatic patients (Canali et al., 2009), and the anti-inflammatory activity of PYC may be best used in combination with inhalation corticosteroids, enabling reduced dosage and frequency of inhalation corticosteroid administration and potentially reducing the need for other asthma medications (Belcaro et al., 2011). Anti-inflammatory properties include alleviating pain and stiffness in arthritis and osteoarthritis patients (Belcaro et al., 2008a), and PYC is a promising antiarthritic drug candidate. PMBE can be used to treat autoimmune diseases since it can block inflammation while normal human horn (HaCaT) cells remain unaffected during short treatment periods. "
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    • "Recent clinical efficacy trials utilizing Garcinia kola [7], pine bark extract-derived bioflavonoids [8] [9], and flavocoxid itself [10] [11] [12] demonstrate a renewed interest in the use of natural molecules for the management of OA. The exact mechanism of action of flavonoid-based therapeutics is unknown. "
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    • "Among the herbal antioxidative supplement, Pycnogenol® has beneficial effects on symptoms of osteoarthritis(41–43). A double-blind, placebo-controlled study reported that Pycnogenol® lowered pain and stiffness and improved symptoms of knee osteoarthritis (flexibility of osteoarthritic joints)(41). "
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