Article

Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan

ETAP - Applied Ethology, 13 rue du Bois de la Champelle, F-54500 Vandoeuvre-lès-Nancy, France. email
The British journal of nutrition (Impact Factor: 3.45). 05/2008; 100(6):1192-9. DOI: 10.1017/S0007114508975607
Source: PubMed

ABSTRACT

Ageing is associated with changes in physiology and morphology; nutritional strategies to decrease morbidity and to prolong life are of high interest. The aim of the study was to investigate the effects of lifelong supplementation with an oligofructose-enriched inulin on morphological and biological markers and lifespan in male and female rats. Male and female rats, age 3 months, were randomised into two groups to receive either a diet with 10 % of an oligofructose-enriched inulin (Synergy 1) or a standard diet (control) for 27 months. The rats were weighed every 2 weeks and their food intake was evaluated on four successive days every 4-6 weeks. Samples were taken at 12, 18 and 24 months of age. During the whole intervention period, male rats receiving Synergy 1 (SYN1-M) displayed lower body weight, cholesterol and plasma triacylglycerolaemia compared with the controls (Cont-M). The survival rate at 24 months of age of SYN1-M rats was 35.3 % greater than that of Cont-M rats. In female rats, the Synergy 1 supplementation (SYN1-F) group also reduced body weight, cholesterol and triacylglycerolaemia levels, but results were less consistent over the experiment. The survival rate at 24 months of age in SYN1-F rats was 33.3 % greater compared with that of the control (Cont-F) group. To conclude, lifelong intervention with Synergy 1 improved biological markers during ageing and survival rate (lifespan) of rats.

  • Source
    • "Cellulose was selected as the insoluble reference fiber that is considered to be inert (Anderson et al., 1994). Inulin is water soluble and non-digestible and some papers have shown efficacy for weight reduction, lipid reduction, and glycemic control, usually at 10% wgt/wgt or greater (Rozan et al., 2008). An sample size of 10 was used for each group and no animals were excluded from the study. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Dietary fiber can reduce insulin resistance, body weight, and hyperlipidemia depending on fiber type, water solubility, and viscosity. PolyGlycopleX(®) (PGX(®)) is a natural, novel water soluble, non-starch polysaccharide complex that with water forms a highly viscous gel compared to other naturally occurring dietary fiber. We determined the effect of dietary PGX(®) vs. cellulose and inulin on the early development of insulin resistance, body weight, hyperlipidemia, and glycemia-induced tissue damage in young Zucker diabetic rats (ZDFs) in fasted and non-fasted states. ZDFs (5 weeks old) were fed a diet containing 5% (wgt/wgt) cellulose, inulin, or PGX(®) for 8 weeks. Body weight, lipids, insulin, and glucose levels were determined throughout the study and homeostasis model assessment (HOMA) was used to measure insulin sensitivity throughout the study in fasted animals. At study termination, insulin sensitivity (oral glucose tolerance test, OGTT) and kidney, liver, and pancreatic histopathology were determined. Body weight and food intake were significantly reduced by PGX(®) vs. inulin and cellulose. Serum insulin in fasted and non-fasted states was significantly reduced by PGX(®) as was non-fasted blood glucose. Insulin resistance, measured as a HOMA score, was significantly reduced by PGX(®) in weeks 5 through 8 as well as terminal OGTT scores in fed and fasted states. Serum total cholesterol was also significantly reduced by PGX(®). PGX(®) significantly reduced histological kidney and hepatic damage in addition to reduced hepatic steatosis and cholestasis. A greater mass of pancreatic β-cells was found in the PGX(®) group. PGX(®) therefore may be a useful dietary additive in the control of the development of the early development of the metabolic syndrome.
    Full-text · Article · Sep 2011 · Frontiers in Pharmacology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ninety cats were assigned to a study to determine the effects of a blend of nutri-tional supplements including antioxidants, a prebiotic, and a blend of omega-3 and omega-6 fatty acids on longevity and quality of life in senior cats. Cats between the ages of 7 and 17 years were blocked to 1 of 3 groups by age, body condition, and gender and fed their assigned diets for their remain-ing lifetime. On average, cats eating the diet containing the nutritional blend lived significantly longer and showed significantly slower deterioration in a number of clini-cal health parameters compared to cats fed a standard adult maintenance control diet. Hematological measurements, body weight, lean body mass, skin thickness, and activity levels also were correlated to survival. Nu-tritional enhancements to the diet of senior cats can improve both length and quality of life.
    No preview · Article · Jan 2008
  • [Show abstract] [Hide abstract]
    ABSTRACT: Der Energiemangel ist nicht nur ein globales Problem, sondern in immer größerem Umfang ein individuelles. Burn-out und Überforderungssyndrom sind mittlerweile in aller Munde. Oftmals ist das Problem ein blockierter Energiehaushalt. Dieser Beitrag stellt einen ganzheitlichen Ansatz vor, um Darmmilieu, Leberstoffwechsel und Säure-Basen-Haushalt nachhaltig zu regenerieren und so Energie zurückzugewinnen. Neben einer gesunden Ernährungs- und Lebensweise spielen dabei Milchsäure-Präbiotika und Citrate eine grundlegende Rolle.
    No preview · Article · Jan 2009 · Komplementäre und Integrative Medizin
Show more