Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor

Department of Pathology, Oregon Health & Science University, Mail code L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Cancer Genetics and Cytogenetics (Impact Factor: 1.93). 05/2008; 182(2):140-3. DOI: 10.1016/j.cancergencyto.2008.01.012
Source: PubMed


Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.

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