Adaptive Evolution of Simian Immunodeficiency Viruses Isolated from 2 Conventional‐Progressor Macaques with Encephalitis

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
The Journal of Infectious Diseases (Impact Factor: 6). 07/2008; 197(12):1695-700. DOI: 10.1086/588671
Source: PubMed


Simian immunodeficiency virus-infected macaques may develop encephalitis, a feature more commonly observed in macaques with
rapid progressive disease than in those with conventional disease. In this report, an analysis of 2 conventional progressors
with encephalitis is described. Phylogenetic analyses of viruses isolated from the cerebrospinal fluid and plasma of both
macaques demonstrated compartmentalization. Furthermore, these viruses appear to have undergone adaptive evolution to preferentially
replicate in their respective cell targets of monocyte-derived macrophages and peripheral blood mononuclear cells. A statistically
significant loss of potential N-linked glycosylation sites in glycoprotein 160 was observed in viruses isolated from the central
nervous system.

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