The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning
The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers.
Available from: Hualin Wang
- "Poly(lactic acid) (PLA) is a biodegradable and biocompatible polyester derived from renewable resources. On the basis of its excellent mechanical properties, biocompatibility and biodegradability , PLA nanofibers   or PLA based nanofibers such as poly(lactide-co-glycolide) nanofibers , PEG–PLA nanofibers  and poly(lactic acid)/poly(ε-caprolactone)  have been widely used in drug carriers for a sustained release. Encouraged by these results, CS/ PLA electrospun nanofibers were used as drug carriers for tetracycline hydrochloride (Tet). "
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ABSTRACT: The present work aimed to evaluate the release behavior of tetracycline hydrochloride loaded chitosan/poly(lactic acid) (Tet-CS/PLA) antimicrobial nanofibrous membranes fabricated via electrospinning technique. The electrospinning solution was a blend of Tet, CS formic acid solution and PLA chloroform/ethanol solution. The interaction between CS and PLA in CS/PLA nanofibers was confirmed to be hydrogen bond. The incorporation of Tet caused a slight decrease in the diameter of nanofibers with Tet content below 30%. Tet-CS/PLA nanofibrous membrane showed a slight initial burst within the first 4 h before a gradual increase in cumulative release, and the release percentage increased with increasing Tet contents. Tet release (Mt/M∞ < 0.6) from the medicated nanofibers could be described by Fickian diffusion model and the release profiles showed two sequential stages. Tet-CS/PLA nanofibrous membranes exhibited an effective and sustainable inhabitance on the growth of Staphylococcus aureus, and the antimicrobial activity increased rapidly with increasing Tet contents below 20%. Furthermore, the incorporation of Tet promoted the degradation of nanofibrous membranes.
- "Various types of surfactants have been used for the preparation of W/O emulsion, and so far there has not been any unanimous agreement on the optimal surfactant type or dosage for the production of uniform nanofibers from polymeric emulsions. The type and the minimum concentration of surfactants used in this study were selected based on the literatures that identified a range of surfactant concentrations, where emulsions could be successfully formed.[9,12,18,19,32333435 Additionally, we varied the concentration of surfactants to find the optimal dosages of these surfactants towards uniform nanofiber formation. "
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ABSTRACT: Producing uniform nanofibers in high quality by electrospinning remains a huge challenge, especially using low concentrated polymer solutions. However, emulsion electrospinning assists to produce nanofibers from less concentrated polymer solutions compared to the traditional electrospinning process. The influence of individual surfactants towards the morphology of the emulsion electrospun poly (ɛ-caprolactone)/bovine serum albumin (PCL/BSA) nanofibers were investigated by using (i) non-ionic surfactant sorbitane monooleate (Span80); (ii) anionic sodium dodecyl sulfate (SDS); and (iii) cationic benzyltriethylammonium chloride, and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer Pluronic F108 of different concentrations. The morphology, along with the chemical and mechanical properties of the fibers, was evaluated by field emission scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy, differential scanning calorimetry, water contact angle, and tensile tester. With the addition of surfactants, the electrospinnability of dilute PCL solution was enhanced, with either branched or uniform fibers were obtained. Electrospinning of an emulsion containing 0.4% (w/v) SDS produced the smallest and the most uniform nanofibers (167 ± 39 nm), which was attributed to the high conductivity of the solution. Analysis revealed that the emulsion electrospun nanofibers containing different surfactants and surfactant concentrations differ in fiber morphology and mechanical properties. Results suggest that surfactants have the ability to modulate the fiber morphology via electrostatic and hydrogen bonding, depending on their chemical structure.
Available from: Amirreza Sohrabi
- "Controlled release drug therapy is a process in which a predetermined concentration of a drug is delivered to a particular target over a specified duration, in a predicted behavior . The main goal of this process is to increase the effectiveness of the drug by means of localizing the delivery, decreasing the side effects, decreasing the number of the administrations and even elimination of specialized administration methods  . Numerous studies have been carried out in order to design, characterize and develop controlled drug delivery systems; the focus has been aimed in particular towards drug delivery systems that utilize biodegradable polymers such as different grades of poly(lactic acid) [3e6]. "
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ABSTRACT: In vitro drug release mechanism of core/shell nanofibers of poly(methyl methacrylate)(PMMA)–nylon6 fabricated through coaxial electrospinning containing different concentrations of ampicillin was investigated. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Korsmeyer–Peppas equation and Fickian diffusion model were utilized to characterize the system. Antibacterial activity of the designed drug delivery system was investigated against Gram-positive Listeria innocua through optical density (OD) measurement. The system showed sustained drug release through three stages; although the release in stage I followed non-Fickian diffusion, Fickian diffusion was proven to be the release mechanism of stages II and III. A significant decrease in the diffusion coefficient from stage II to stage III was observed, which is believed to be the consequence of crystallization of fibers as a result of long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density (OD) measurements against Gram-positive L. innocua.
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