Primary cutaneous anaplastic large cell lymphoma successfully treated with low-dose oral methotrexate

ArticleinEuropean journal of dermatology: EJD 18(3):360-1 · May 2008with11 Reads
DOI: 10.1684/ejd.2008.0420 · Source: PubMed
  • [Show abstract] [Hide abstract] ABSTRACT: To explore the clinical presentation, therapy and prognosis study of primary cutaneous anaplastic large cell lymphoma (PCALCL). We reviewed and analyzed ten cases of PCALCL receiving treatment at our hospital from January 1999 to January 2009. There were 8 males and 2 females with a median age of 48 years old (range: 22 - 69). There were single subcutaneous nodule (n = 7) and multiple nodules (n = 3). And the lesions could be found on head and neck (n = 5), trunk (n = 3) and all over body (n = 2). The lesions appeared red, solid and stable subcutaneous nodules. Partial lesions had a spontaneous regression and new nodules appeared at the same or different sites. Two patients had lymphadenopathy and one had bone involvement with anaplastic lymphoma kinase (ALK) positive and high cell proliferation ratio index (ki-67 > 80%). Seven cases with single lesion received surgical excision plus radiotherapy, chemotherapy or radiochemotherapy, one case recurred, six cases survived without disease. Three cases with multiple lesions received systemic chemotherapy mainly in combination with radiotherapy or biotherapy, two cases recurred and one case survived without disease. The median follow-up was 44 months (range: 9 - 95), progression free survival 89% and overall survival 100%. PCALCL is found more commonly in males. Visceral and lymph node involvement are rare. The patients with single lesion have a longer disease-free survival than those with multiple lesions after surgical excision in combination with chemotherapy or radiotherapy. Multiple lesions can not be cured.
    Article · May 2010
  • [Show abstract] [Hide abstract] ABSTRACT: Primary cutaneous CD30+ lymphoproliferative disorders are the second most common type of primary cutaneous lymphomas. Involvement of the ocular adnexa is rare. Very few have been reported affecting the eyelid primarily. The authors present 2 patients with primary cutaneous anaplastic large-cell lymphoma involving the eyelid alone. Systemic workup excluded disease elsewhere. Both patients showed complete regression of their lesion following biopsy only and no other treatment, albeit with limited follow up. A surgically induced inflammatory or immune-mediated response could have played a role in the regression of these lesions.
    Article · Apr 2011
  • [Show abstract] [Hide abstract] ABSTRACT: Since the recognition of the anaplastic large-cell lymphomas in the 1980s, much has been learned about the diagnosis, clinical presentation, and treatment of these malignant conditions. The systemic and primary cutaneous types of anaplastic large cell lymphomas have been differentiated on clinical and immunophenotypical findings, but further research is required to elucidate their exact etiologies and pathogeneses. Primary cutaneous anaplastic large-cell lymphoma has a 95% disease-specific 5-year survival, owing partly to the relatively benign course of the disease and partly to the variety of effective treatments that are available. As with many other oncological diseases, new drugs are continually being tested and developed, with immunotherapy and biological response modifiers showing promise.
    Article · May 2011
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