Predictors of Cancer-Related Fatigue in Women With Breast Cancer Before, During, and After Adjuvant Therapy

Center for Enhancing Quality of Life in Chronic Illness, Indiana University School of Nursing, Indianapolis, Indiana 46202, USA.
Cancer nursing (Impact Factor: 1.97). 03/2008; 31(2):134-44. DOI: 10.1097/01.NCC.0000305704.84164.54
Source: PubMed


The purpose of this longitudinal study was to examine potential predictors of cancer-related fatigue (CRF) before, during, and after adjuvant therapy in women with breast cancer. A convenience sample of 44 women postsurgery (M = 18) aged 38 to 77 years (M = 52) were recruited from a Southern breast clinic. Based on Piper's Integrated Fatigue Model, the women (1) completed questionnaires assessing innate host factors (age, income, and education level), disease and treatment patterns (disease stage, surgery type, and adjuvant therapy), psychological patterns (perceived stress, mood disturbance, and optimism), social patterns (type and satisfaction with social support) and (2) provided a blood sample to examine regulation patterns (morning cortisol levels, interleukin-1 beta, tumor necrosis factor alpha, and natural killer cell activity) before adjuvant therapy. The Piper Fatigue Scale-Revised was completed at all 3 time points. Mood disturbance was the most significant predictor of CRF at all time points. Interleukin-1 beta predicted CRF levels before adjuvant therapy and morning cortisol before adjuvant therapy predicted CRF during and after adjuvant therapy. These findings suggest that interventions to reduce mood disturbances might be effective in decreasing CRF. Further research regarding the physiological mechanisms underlying the relationships between CRF, mood disturbance, interleukin-1 beta, and cortisol is needed.

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Available from: Diane M Von Ah, Jul 02, 2014
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    • "Although there is a significant body of literature evaluating HRQoL in women with breast cancer,[9,10] much of this work has been focused on survivorship,[11-13] women treated in adjuvant settings,[14-16] or in women with recurrent disease[17-19]. HRQoL research with mBC patients has occurred primarily in the clinical trial setting,[20-22] has included multiple cancer types,[23] and has focused on characterizing HRQoL at either a single point in time or at a couple of fixed time points[23,24]. "
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