Late-Onset Hypersensitivity Reaction With Leukopenia and Thrombocytopenia Induced by Oxcarbazepine Treatment in a Patient With Schizoaffective Disorder

The Journal of Clinical Psychiatry (Impact Factor: 5.5). 05/2008; 69(4):676-8. DOI: 10.4088/JCP.v69n0423b
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Available from: Yi-Wei Yeh, Jun 04, 2015
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    ABSTRACT: This chapter presents the studies of the effects of antiepileptic drugs. Clinicians have only recently realized that chronic adverse effects of antiepileptic drugs, mainly those involving central nervous system, may be more disabling to the patient than the seizures themselves. Up to a few years ago, the historical belief that seizure frequency is the major determinant of health-related quality of life and that adverse reactions are merely a secondary end-point was the prevalent opinion. It has been shown that changes in seizure rate among patients with drug-resistant epilepsy are only modestly correlated with the quality of life, while adverse reactions and depression are critical determinants of subjective health status. In an attempt to define specific patterns of adverse reactions and their clinical relevance to subjective health status, 200 subjects with epilepsy completed validated self-report health assessments, including the adverse event profile and quality of life in epilepsy inventory. The mean number of adverse reactions per subject was 6.5.
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